STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (208 aa)    
Predicted Functional Partners:
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
 
 
 0.965
rpoZ
DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
  
  
 0.963
apt
Adenine phosphoribosyltransferase.
  
 
 0.953
hpt
Probable hypoxanthine/xanthine/guanine phosphoribosyltransferase.
  
  
 0.938
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
   
 0.931
spoT
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase:(p)ppGpp synthetase II; No direct information on the functions of the TGS domain, but its presence in two types of regulatory proteins (the GTPases and guanosine polyphosphate phosphohydrolases/synthetases) suggests a ligand (most likely nucleotide)-binding, regulatory role; Citation: Koonin E.V., Grishin N.V., Aravind L., Wolf Y.I. Evolution of aminoacyl-tRNA synthetases--analysis of unique domain architectures and phylogenetic trees reveals a complex history of horizontal gene transfer events. Genome Res. 9: 689- 710 (1999).
  
 
 0.931
nrdA
Ribonucleoside-diphosphate reductase class Ia alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
     
 0.910
nrdB
Ribonucleoside-diphosphate reductase class Ia beta subunit; One copy each of nrdA and nrdB have been identified in Psychrobacter 273-4.
     
 0.905
Psyc_0689
Hypothetical protein.
     
  0.900
Psyc_1962
Conserved hypothetical protein.
     
  0.900
Your Current Organism:
Psychrobacter arcticus
NCBI taxonomy Id: 259536
Other names: P. arcticus 273-4, Psychrobacter arcticus 273-4, Psychrobacter arcticus str. 273-4, Psychrobacter arcticus strain 273-4, Psychrobacter sp. 273-4
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