node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aroA | hisC | Psyc_1184 | Psyc_1185 | 3-phosphoshikimate 1-carboxyvinyltransferase / prephenate dehydrogenase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.998 |
aroA | hisC2 | Psyc_1184 | Psyc_1901 | 3-phosphoshikimate 1-carboxyvinyltransferase / prephenate dehydrogenase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Histidinol phosphate aminotransferase apoenzyme; One of two hisC genes in the Psychrobacter 273-4 genome; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.995 |
aroA | hisD | Psyc_1184 | Psyc_1902 | 3-phosphoshikimate 1-carboxyvinyltransferase / prephenate dehydrogenase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.419 |
aroA | hisG | Psyc_1184 | Psyc_1903 | 3-phosphoshikimate 1-carboxyvinyltransferase / prephenate dehydrogenase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.480 |
aroA | pheA | Psyc_1184 | Psyc_1186 | 3-phosphoshikimate 1-carboxyvinyltransferase / prephenate dehydrogenase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Prephenate dehydratase; Contains 3 domains: chorismate mutase, prephenate dehydratase, and an ACT (amino acid synthesis regulatory domain). This enzyme is bifunctional in the phenylalanine synthesis pathway. | 0.998 |
aroA | tyrB | Psyc_1184 | Psyc_1403 | 3-phosphoshikimate 1-carboxyvinyltransferase / prephenate dehydrogenase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Aromatic amino acid aminotransferase apoenzyme. | 0.949 |
hisB | hisC | Psyc_2121 | Psyc_1185 | Imidazoleglycerol-phosphate dehydratase; This orf is probably the monofunctional variety of hisB. | Aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.998 |
hisB | hisC2 | Psyc_2121 | Psyc_1901 | Imidazoleglycerol-phosphate dehydratase; This orf is probably the monofunctional variety of hisB. | Histidinol phosphate aminotransferase apoenzyme; One of two hisC genes in the Psychrobacter 273-4 genome; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.997 |
hisB | hisD | Psyc_2121 | Psyc_1902 | Imidazoleglycerol-phosphate dehydratase; This orf is probably the monofunctional variety of hisB. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.997 |
hisB | hisF | Psyc_2121 | Psyc_2068 | Imidazoleglycerol-phosphate dehydratase; This orf is probably the monofunctional variety of hisB. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.997 |
hisB | hisG | Psyc_2121 | Psyc_1903 | Imidazoleglycerol-phosphate dehydratase; This orf is probably the monofunctional variety of hisB. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.980 |
hisB | hisH | Psyc_2121 | Psyc_2120 | Imidazoleglycerol-phosphate dehydratase; This orf is probably the monofunctional variety of hisB. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisB | hisI | Psyc_2121 | Psyc_1999 | Imidazoleglycerol-phosphate dehydratase; This orf is probably the monofunctional variety of hisB. | phosphoribosyl-AMP cyclohydrolase; This orf aligns to domains of both pyrophosphohydrolase and cyclohydrolase functions, suggesting a bifunctional enzyme; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
hisB | pheA | Psyc_2121 | Psyc_1186 | Imidazoleglycerol-phosphate dehydratase; This orf is probably the monofunctional variety of hisB. | Prephenate dehydratase; Contains 3 domains: chorismate mutase, prephenate dehydratase, and an ACT (amino acid synthesis regulatory domain). This enzyme is bifunctional in the phenylalanine synthesis pathway. | 0.552 |
hisC | aroA | Psyc_1185 | Psyc_1184 | Aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 3-phosphoshikimate 1-carboxyvinyltransferase / prephenate dehydrogenase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.998 |
hisC | hisB | Psyc_1185 | Psyc_2121 | Aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Imidazoleglycerol-phosphate dehydratase; This orf is probably the monofunctional variety of hisB. | 0.998 |
hisC | hisC2 | Psyc_1185 | Psyc_1901 | Aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Histidinol phosphate aminotransferase apoenzyme; One of two hisC genes in the Psychrobacter 273-4 genome; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.910 |
hisC | hisD | Psyc_1185 | Psyc_1902 | Aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.983 |
hisC | hisF | Psyc_1185 | Psyc_2068 | Aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.868 |
hisC | hisG | Psyc_1185 | Psyc_1903 | Aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.816 |