node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFN01321.1 | SFN01337.1 | SAMN05216207_1006112 | SAMN05216207_1006113 | 3-isopropylmalate dehydratase, small subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit. | 0.999 |
SFN01321.1 | SFN01354.1 | SAMN05216207_1006112 | SAMN05216207_1006114 | 3-isopropylmalate dehydratase, small subunit. | Phosphoenolpyruvate mutase. | 0.885 |
SFN01321.1 | SFN11458.1 | SAMN05216207_1006112 | SAMN05216207_100858 | 3-isopropylmalate dehydratase, small subunit. | hydroxymethylglutaryl-CoA lyase. | 0.796 |
SFN01321.1 | SFN88253.1 | SAMN05216207_1006112 | SAMN05216207_102382 | 3-isopropylmalate dehydratase, small subunit. | Acetolactate synthase, small subunit. | 0.904 |
SFN01321.1 | ilvC | SAMN05216207_1006112 | SAMN05216207_102381 | 3-isopropylmalate dehydratase, small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.926 |
SFN01321.1 | ilvD | SAMN05216207_1006112 | SAMN05216207_100271 | 3-isopropylmalate dehydratase, small subunit. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.811 |
SFN01321.1 | leuA | SAMN05216207_1006112 | SAMN05216207_1014135 | 3-isopropylmalate dehydratase, small subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.986 |
SFN01321.1 | leuB | SAMN05216207_1006112 | SAMN05216207_102371 | 3-isopropylmalate dehydratase, small subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.992 |
SFN01321.1 | leuC | SAMN05216207_1006112 | SAMN05216207_102363 | 3-isopropylmalate dehydratase, small subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.998 |
SFN01321.1 | leuD | SAMN05216207_1006112 | SAMN05216207_102362 | 3-isopropylmalate dehydratase, small subunit. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.908 |
SFN01337.1 | SFN01321.1 | SAMN05216207_1006113 | SAMN05216207_1006112 | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit. | 3-isopropylmalate dehydratase, small subunit. | 0.999 |
SFN01337.1 | SFN01354.1 | SAMN05216207_1006113 | SAMN05216207_1006114 | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit. | Phosphoenolpyruvate mutase. | 0.888 |
SFN01337.1 | SFN11458.1 | SAMN05216207_1006113 | SAMN05216207_100858 | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit. | hydroxymethylglutaryl-CoA lyase. | 0.797 |
SFN01337.1 | SFN88253.1 | SAMN05216207_1006113 | SAMN05216207_102382 | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit. | Acetolactate synthase, small subunit. | 0.903 |
SFN01337.1 | ilvC | SAMN05216207_1006113 | SAMN05216207_102381 | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.950 |
SFN01337.1 | ilvD | SAMN05216207_1006113 | SAMN05216207_100271 | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.916 |
SFN01337.1 | leuA | SAMN05216207_1006113 | SAMN05216207_1014135 | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.988 |
SFN01337.1 | leuB | SAMN05216207_1006113 | SAMN05216207_102371 | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.997 |
SFN01337.1 | leuC | SAMN05216207_1006113 | SAMN05216207_102363 | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.922 |
SFN01337.1 | leuD | SAMN05216207_1006113 | SAMN05216207_102362 | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.999 |