node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFM82796.1 | SFN27194.1 | SAMN05216207_1003134 | SAMN05216207_1011148 | Uncharacterized conserved protein, DUF427 family. | L-histidine Nalpha-methyltransferase. | 0.520 |
SFM82796.1 | egtD | SAMN05216207_1003134 | SAMN05216207_101835 | Uncharacterized conserved protein, DUF427 family. | L-histidine Nalpha-methyltransferase; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. | 0.516 |
SFM89901.1 | SFN27194.1 | SAMN05216207_1004168 | SAMN05216207_1011148 | Uncharacterized membrane protein YeaQ/YmgE, transglycosylase-associated protein family. | L-histidine Nalpha-methyltransferase. | 0.717 |
SFM89901.1 | egtD | SAMN05216207_1004168 | SAMN05216207_101835 | Uncharacterized membrane protein YeaQ/YmgE, transglycosylase-associated protein family. | L-histidine Nalpha-methyltransferase; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. | 0.717 |
SFM97522.1 | SFN27194.1 | SAMN05216207_1005237 | SAMN05216207_1011148 | Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain. | L-histidine Nalpha-methyltransferase. | 0.824 |
SFM97522.1 | egtA | SAMN05216207_1005237 | SAMN05216207_101832 | Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain. | Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine. | 0.551 |
SFM97522.1 | egtC | SAMN05216207_1005237 | SAMN05216207_101834 | Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain. | Glutamine amidotransferase; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. | 0.745 |
SFM97522.1 | egtD | SAMN05216207_1005237 | SAMN05216207_101835 | Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain. | L-histidine Nalpha-methyltransferase; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. | 0.824 |
SFN27194.1 | SFM82796.1 | SAMN05216207_1011148 | SAMN05216207_1003134 | L-histidine Nalpha-methyltransferase. | Uncharacterized conserved protein, DUF427 family. | 0.520 |
SFN27194.1 | SFM89901.1 | SAMN05216207_1011148 | SAMN05216207_1004168 | L-histidine Nalpha-methyltransferase. | Uncharacterized membrane protein YeaQ/YmgE, transglycosylase-associated protein family. | 0.717 |
SFN27194.1 | SFM97522.1 | SAMN05216207_1011148 | SAMN05216207_1005237 | L-histidine Nalpha-methyltransferase. | Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain. | 0.824 |
SFN27194.1 | SFN27212.1 | SAMN05216207_1011148 | SAMN05216207_1011149 | L-histidine Nalpha-methyltransferase. | Iron-containing redox enzyme. | 0.776 |
SFN27194.1 | SFN27232.1 | SAMN05216207_1011148 | SAMN05216207_1011150 | L-histidine Nalpha-methyltransferase. | Iron-binding zinc finger CDGSH type. | 0.775 |
SFN27194.1 | SFN27248.1 | SAMN05216207_1011148 | SAMN05216207_1011151 | L-histidine Nalpha-methyltransferase. | Release factor glutamine methyltransferase. | 0.775 |
SFN27194.1 | egtA | SAMN05216207_1011148 | SAMN05216207_101832 | L-histidine Nalpha-methyltransferase. | Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine. | 0.872 |
SFN27194.1 | egtB | SAMN05216207_1011148 | SAMN05216207_101833 | L-histidine Nalpha-methyltransferase. | iron(II)-dependent oxidoreductase; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine; Belongs to the EgtB family. | 0.997 |
SFN27194.1 | egtC | SAMN05216207_1011148 | SAMN05216207_101834 | L-histidine Nalpha-methyltransferase. | Glutamine amidotransferase; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. | 0.929 |
SFN27194.1 | egtD | SAMN05216207_1011148 | SAMN05216207_101835 | L-histidine Nalpha-methyltransferase. | L-histidine Nalpha-methyltransferase; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. | 0.856 |
SFN27212.1 | SFN27194.1 | SAMN05216207_1011149 | SAMN05216207_1011148 | Iron-containing redox enzyme. | L-histidine Nalpha-methyltransferase. | 0.776 |
SFN27212.1 | SFN27232.1 | SAMN05216207_1011149 | SAMN05216207_1011150 | Iron-containing redox enzyme. | Iron-binding zinc finger CDGSH type. | 0.956 |