| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AQQ66636.1 | AQQ68209.1 | Mag101_02470 | Mag101_11600 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Bifunctional tetrahydrofolate synthase/dihydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | 0.927 |
| AQQ66636.1 | gcvT | Mag101_02470 | Mag101_09620 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine cleavage system protein T; Catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.914 |
| AQQ66636.1 | gcvT-2 | Mag101_02470 | Mag101_02405 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.914 |
| AQQ66636.1 | glyA | Mag101_02470 | Mag101_03010 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.935 |
| AQQ66636.1 | thyA | Mag101_02470 | Mag101_02465 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
| AQQ67720.1 | AQQ69093.1 | Mag101_08765 | Mag101_16760 | 5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Haloacid dehalogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.900 |
| AQQ67720.1 | thyA | Mag101_08765 | Mag101_02465 | 5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.900 |
| AQQ67720.1 | tmk | Mag101_08765 | Mag101_08850 | 5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.900 |
| AQQ68209.1 | AQQ66636.1 | Mag101_11600 | Mag101_02470 | Bifunctional tetrahydrofolate synthase/dihydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.927 |
| AQQ68209.1 | folD | Mag101_11600 | Mag101_07250 | Bifunctional tetrahydrofolate synthase/dihydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.473 |
| AQQ68209.1 | glyA | Mag101_11600 | Mag101_03010 | Bifunctional tetrahydrofolate synthase/dihydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.697 |
| AQQ68209.1 | thyA | Mag101_11600 | Mag101_02465 | Bifunctional tetrahydrofolate synthase/dihydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.854 |
| AQQ68963.1 | folD | Mag101_15975 | Mag101_07250 | Methylenetetrahydrofolate reductase [NAD(P)H]; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.933 |
| AQQ68963.1 | gcvT | Mag101_15975 | Mag101_09620 | Methylenetetrahydrofolate reductase [NAD(P)H]; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system protein T; Catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.919 |
| AQQ68963.1 | gcvT-2 | Mag101_15975 | Mag101_02405 | Methylenetetrahydrofolate reductase [NAD(P)H]; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.919 |
| AQQ68963.1 | glyA | Mag101_15975 | Mag101_03010 | Methylenetetrahydrofolate reductase [NAD(P)H]; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.946 |
| AQQ68963.1 | thyA | Mag101_15975 | Mag101_02465 | Methylenetetrahydrofolate reductase [NAD(P)H]; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.928 |
| AQQ69093.1 | AQQ67720.1 | Mag101_16760 | Mag101_08765 | Haloacid dehalogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.900 |
| AQQ69093.1 | thyA | Mag101_16760 | Mag101_02465 | Haloacid dehalogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.906 |
| AQQ69093.1 | tmk | Mag101_16760 | Mag101_08850 | Haloacid dehalogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.903 |
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