STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
guaCGMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. (326 aa)    
Predicted Functional Partners:
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.
 
 0.999
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
 
 0.990
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase.
  
 
 0.953
xpt
Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
  
 
 0.934
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
 
  
 0.932
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
 
0.928
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
  
 
 0.924
hpt
Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
    
 0.918
AU385_00460
Bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase.
    
 0.905
AU385_07125
Bifunctional metallophosphatase/5'-nucleotidase; Belongs to the 5'-nucleotidase family.
    
 0.905
Your Current Organism:
Bacillus halotolerans
NCBI taxonomy Id: 260554
Other names: ATCC 25096, B. halotolerans, Bacillus axarquiensis, Bacillus axarquiensis Ruiz-Garcia et al. 2005 emend. Dunlap et al. 2016, Bacillus malacitensis, Bacillus malacitensis Ruiz-Garcia et al. 2005, Brevibacterium halotolerans, CCUG 47676, CECT 5687 [[Bacillus malacitensis]], CECT 5688 [[Bacillus axarquiensis]], CIP 108772 [[Bacillus axarquiensis]], CIP 67.21, DSM 8802, JCM 12400, LMG 22476 [[Bacillus axarquiensis]], LMG 22477 [[Bacillus malacitensis]], LMG:22476 [[Bacillus axarquiensis]], LMG:22477 [[Bacillus malacitensis]], NRRL B-41617 [[Bacillus axarquiensis]], strain CR-119 [[Bacillus axarquiensis]], strain CR-95 [[Bacillus malacitensis]]
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