Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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sepFCell division protein SepF; Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA. (150 aa)    
Predicted Functional Partners:
ftsZ
Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
  
 
 0.995
AU385_09000
YggT family protein.
  
  
 0.990
ftsA
Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family.
  
 
 0.972
AU385_09010
Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
  
  
 0.970
AU385_08990
Septum site-determining protein DivIVA.
  
  
 0.955
AU385_08995
RNA-binding protein.
 
  
 0.941
pgeF
Polyphenol oxidase; Belongs to the multicopper oxidase YfiH/RL5 family.
  
  
 0.872
ezrA
Septation ring formation regulator EzrA; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family.
    
 
 0.872
zapA
Cell division protein ZapA; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.
    
 
 0.871
minC
Probable septum site-determining protein MinC; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization; Belongs to the MinC family.
  
  
 0.844
Your Current Organism:
Bacillus halotolerans
NCBI taxonomy Id: 260554
Other names: ATCC 25096, B. halotolerans, Bacillus axarquiensis, Bacillus axarquiensis Ruiz-Garcia et al. 2005 emend. Dunlap et al. 2016, Bacillus malacitensis, Bacillus malacitensis Ruiz-Garcia et al. 2005, Brevibacterium halotolerans, CCUG 47676, CECT 5687 [[Bacillus malacitensis]], CECT 5688 [[Bacillus axarquiensis]], CIP 108772 [[Bacillus axarquiensis]], CIP 67.21, DSM 8802, JCM 12400, LMG 22476 [[Bacillus axarquiensis]], LMG 22477 [[Bacillus malacitensis]], LMG:22476 [[Bacillus axarquiensis]], LMG:22477 [[Bacillus malacitensis]], NRRL B-41617 [[Bacillus axarquiensis]], strain CR-119 [[Bacillus axarquiensis]], strain CR-95 [[Bacillus malacitensis]]
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