STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AU385_20265Guanine permease. (432 aa)    
Predicted Functional Partners:
AU385_20270
Dipeptidase PepV.
       0.573
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.
     
 0.489
AU385_08960
Uracil permease.
 
  
 0.476
purL
Phosphoribosylformylglycinamidine synthase subunit PurL; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...]
  
  
 0.446
purE
N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
  
    0.440
purK
N5-carboxyaminoimidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
  
    0.432
purD
Phosphoribosylamine--glycine ligase; Belongs to the GARS family.
  
  
 0.430
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family.
  
  
 0.418
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
  
 0.414
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase.
  
  
 0.407
Your Current Organism:
Bacillus halotolerans
NCBI taxonomy Id: 260554
Other names: ATCC 25096, B. halotolerans, Bacillus axarquiensis, Bacillus axarquiensis Ruiz-Garcia et al. 2005 emend. Dunlap et al. 2016, Bacillus malacitensis, Bacillus malacitensis Ruiz-Garcia et al. 2005, Brevibacterium halotolerans, CCUG 47676, CECT 5687 [[Bacillus malacitensis]], CECT 5688 [[Bacillus axarquiensis]], CIP 108772 [[Bacillus axarquiensis]], CIP 67.21, DSM 8802, JCM 12400, LMG 22476 [[Bacillus axarquiensis]], LMG 22477 [[Bacillus malacitensis]], LMG:22476 [[Bacillus axarquiensis]], LMG:22477 [[Bacillus malacitensis]], NRRL B-41617 [[Bacillus axarquiensis]], strain CR-119 [[Bacillus axarquiensis]], strain CR-95 [[Bacillus malacitensis]]
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