CUO73396.1 protein (Intestinibacter bartlettii)

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

CUO73396.1

Rrf2 family protein. (139 aa)

Predicted Functional Partners:

csdB

0.674

iscS2

0.674

iscS

0.674

pmbA

0.554

tldD

0.554

CUO73303.1

0.433

nifU

0.429

CUP02735.1

0.429

GltD

0.423

porA_1

0.420

Your Current Organism:

Intestinibacter bartlettii

NCBI taxonomy Id: 261299
Other names: ATCC BAA-827, CCUG 48940, Clostridium bartlettii, Clostridium bartlettii Song et al. 2004, DSM 16795, I. bartlettii, Intestinibacter bartlettii (Song et al. 2004) Gerritsen et al. 2014, WAL 16138

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUO73303.1	CUO73396.1	ERS852493_00793	ERS852493_00797	SufBD protein.	Rrf2 family protein.	0.433
CUO73303.1	CUP02735.1	ERS852493_00793	ERS852493_01709	SufBD protein.	NifU-like protein involved in Fe-S cluster formation.	0.737
CUO73303.1	nifU	ERS852493_00793	ERS852493_01078	SufBD protein.	NifU-like protein.	0.801
CUO73303.1	pmbA	ERS852493_00793	ERS852493_00795	SufBD protein.	Regulatory protease.	0.457
CUO73303.1	tldD	ERS852493_00793	ERS852493_00796	SufBD protein.	Regulatory protease.	0.457
CUO73396.1	CUO73303.1	ERS852493_00797	ERS852493_00793	Rrf2 family protein.	SufBD protein.	0.433
CUO73396.1	CUP02735.1	ERS852493_00797	ERS852493_01709	Rrf2 family protein.	NifU-like protein involved in Fe-S cluster formation.	0.429
CUO73396.1	GltD	ERS852493_00797	ERS852493_01409	Rrf2 family protein.	NADPH-dependent glutamate synthase beta chain.	0.423
CUO73396.1	csdB	ERS852493_00797	ERS852493_00324	Rrf2 family protein.	Cysteine desulfurase CsdB.	0.674
CUO73396.1	iscS	ERS852493_00797	ERS852493_01774	Rrf2 family protein.	Putative cysteine desulfurase.	0.674
CUO73396.1	iscS2	ERS852493_00797	ERS852493_01079	Rrf2 family protein.	Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.	0.674
CUO73396.1	nifU	ERS852493_00797	ERS852493_01078	Rrf2 family protein.	NifU-like protein.	0.429
CUO73396.1	pmbA	ERS852493_00797	ERS852493_00795	Rrf2 family protein.	Regulatory protease.	0.554
CUO73396.1	porA_1	ERS852493_00797	ERS852493_00196	Rrf2 family protein.	Pyruvate-flavodoxin oxidoreductase.	0.420
CUO73396.1	tldD	ERS852493_00797	ERS852493_00796	Rrf2 family protein.	Regulatory protease.	0.554
CUP02735.1	CUO73303.1	ERS852493_01709	ERS852493_00793	NifU-like protein involved in Fe-S cluster formation.	SufBD protein.	0.737
CUP02735.1	CUO73396.1	ERS852493_01709	ERS852493_00797	NifU-like protein involved in Fe-S cluster formation.	Rrf2 family protein.	0.429
CUP02735.1	GltD	ERS852493_01709	ERS852493_01409	NifU-like protein involved in Fe-S cluster formation.	NADPH-dependent glutamate synthase beta chain.	0.933
CUP02735.1	csdB	ERS852493_01709	ERS852493_00324	NifU-like protein involved in Fe-S cluster formation.	Cysteine desulfurase CsdB.	0.953
CUP02735.1	iscS	ERS852493_01709	ERS852493_01774	NifU-like protein involved in Fe-S cluster formation.	Putative cysteine desulfurase.	0.953

page 1 of 3

Network Stats

number of nodes:

3

number of edges:

2

average node degree:

1.33

avg. local clustering coefficient:

0.667

expected number of edges:

2

PPI enrichment p-value:

0.526

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007165

Signal transduction

6 of 143

1.2

1.18

0.00017

GO:0050896

Response to stimulus

9 of 320

1.03

1.14

2.79e-06

GO:0050794

Regulation of cellular process

10 of 417

0.96

1.05

1.33e-06

GO:0000160

Phosphorelay signal transduction system

4 of 80

1.28

0.9

0.0058

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016772

Transferase activity, transferring phosphorus-containing groups

5 of 171

1.04

0.58

0.0315

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016021

Integral component of membrane

8 of 731

0.62

0.43

0.0116

GO:0016020

Membrane

9 of 1060

0.51

0.36

0.0116

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2286

His Kinase A (phosphoacceptor) domain, and PAS-associated, C-terminal

11 of 30

2.14

7.51

1.73e-20

CL:2287

His Kinase A (phosphoacceptor) domain, and PAS fold

9 of 25

2.13

6.36

1.89e-16

CL:2288

PAS-associated, C-terminal, and His Kinase A (phosphoacceptor) domain

6 of 18

2.1

4.22

3.75e-10

CL:2308

His Kinase A (phosphoacceptor) domain

3 of 8

2.15

2.05

9.45e-05

CL:2289

PAS-associated, C-terminal

3 of 10

2.05

1.91

0.00016

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

9 of 332

1.01

1.15

8.50e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045121

Membrane raft

2 of 4

2.28

1.06

0.0110

GOCC:0016020

Membrane

8 of 515

0.77

0.61

0.0016

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

9 of 62

1.74

3.97

4.21e-13

KW-0418

Kinase

10 of 88

1.63

3.66

7.67e-14

KW-0175

Coiled coil

7 of 416

0.8

0.65

0.0013

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR005467

Histidine kinase domain

10 of 38

2.0

5.76

2.20e-16

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

9 of 31

2.04

5.6

4.75e-15

IPR003594

Histidine kinase/HSP90-like ATPase

10 of 46

1.91

5.28

5.97e-16

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

8 of 27

2.05

5.1

3.22e-13

IPR036890

Histidine kinase/HSP90-like ATPase superfamily

10 of 54

1.84

4.87

1.69e-15

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00388

His Kinase A (phosphoacceptor) domain

9 of 32

2.03

5.73

9.57e-16

SM00387

Histidine kinase-like ATPases

10 of 52

1.86

5.1

2.83e-16

SM00448

cheY-homologous receiver domain

9 of 53

1.81

4.45

3.66e-14

SM00091

PAS domain

5 of 38

1.7

2.39

1.06e-06

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

3 of 30

1.58

1.27

0.0015

(more ...)

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