node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SJZ29712.1 | SJZ50437.1 | SAMN02745149_00216 | SAMN02745149_01487 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | methionyl-tRNA synthetase C-terminal region/beta chain. | 0.936 |
SJZ29712.1 | def | SAMN02745149_00216 | SAMN02745149_01491 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | 0.774 |
SJZ29712.1 | fhs | SAMN02745149_00216 | SAMN02745149_01420 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.934 |
SJZ29712.1 | fmt | SAMN02745149_00216 | SAMN02745149_01490 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.905 |
SJZ29712.1 | folD | SAMN02745149_00216 | SAMN02745149_01511 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.752 |
SJZ29712.1 | glyA | SAMN02745149_00216 | SAMN02745149_00686 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.921 |
SJZ29712.1 | metG | SAMN02745149_00216 | SAMN02745149_00776 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.936 |
SJZ29712.1 | purN | SAMN02745149_00216 | SAMN02745149_02157 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Phosphoribosylglycinamide formyltransferase-1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.898 |
SJZ31479.1 | SJZ50437.1 | SAMN02745149_00596 | SAMN02745149_01487 | Phosphoribosylformylglycinamidine synthase. | methionyl-tRNA synthetase C-terminal region/beta chain. | 0.903 |
SJZ31479.1 | fhs | SAMN02745149_00596 | SAMN02745149_01420 | Phosphoribosylformylglycinamidine synthase. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.939 |
SJZ31479.1 | fmt | SAMN02745149_00596 | SAMN02745149_01490 | Phosphoribosylformylglycinamidine synthase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.919 |
SJZ31479.1 | folD | SAMN02745149_00596 | SAMN02745149_01511 | Phosphoribosylformylglycinamidine synthase. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.845 |
SJZ31479.1 | glyA | SAMN02745149_00596 | SAMN02745149_00686 | Phosphoribosylformylglycinamidine synthase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.971 |
SJZ31479.1 | metG | SAMN02745149_00596 | SAMN02745149_00776 | Phosphoribosylformylglycinamidine synthase. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.903 |
SJZ31479.1 | purN | SAMN02745149_00596 | SAMN02745149_02157 | Phosphoribosylformylglycinamidine synthase. | Phosphoribosylglycinamide formyltransferase-1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.998 |
SJZ50437.1 | SJZ29712.1 | SAMN02745149_01487 | SAMN02745149_00216 | methionyl-tRNA synthetase C-terminal region/beta chain. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.936 |
SJZ50437.1 | SJZ31479.1 | SAMN02745149_01487 | SAMN02745149_00596 | methionyl-tRNA synthetase C-terminal region/beta chain. | Phosphoribosylformylglycinamidine synthase. | 0.903 |
SJZ50437.1 | def | SAMN02745149_01487 | SAMN02745149_01491 | methionyl-tRNA synthetase C-terminal region/beta chain. | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | 0.867 |
SJZ50437.1 | fmt | SAMN02745149_01487 | SAMN02745149_01490 | methionyl-tRNA synthetase C-terminal region/beta chain. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.901 |
SJZ50437.1 | glyA | SAMN02745149_01487 | SAMN02745149_00686 | methionyl-tRNA synthetase C-terminal region/beta chain. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.491 |