STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ligDNA ligase-1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (527 aa)    
Predicted Functional Partners:
SBT45596.1
DNA polymerase III sliding clamp (beta) subunit, PCNA homolog.
   
 0.964
SBT49777.1
DNA polymerase-3 subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...]
   
 0.964
ligA
DNA ligase (NAD+); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
     
 0.960
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.929
SBT40616.1
ATP-dependent DNA helicase RecQ.
  
 0.866
SBT41921.1
5'-3' exonuclease.
   
 0.865
SBT37984.1
Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED.
   
 0.848
ku
DNA end-binding protein Ku; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.826
SBT39785.1
DNA ligase D, polymerase domain-containing protein.
  
 0.805
SBT36909.1
DNA ligase D.
  
 0.803
Your Current Organism:
Micromonospora auratinigra
NCBI taxonomy Id: 261654
Other names: DSM 44815, JCM 12357, M. auratinigra, Micromonospora aurantionigra, Micromonospora auratinigra corrig. Thawai et al. 2004, Micromonospora sp. TT1-11, NBRC 101913, PCU 239, PCU:239, strain TT1-11
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