node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDG96695.1 | SDG97575.1 | SAMN04489796_1011056 | SAMN04489796_1011077 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Acetolactate synthase, small subunit. | 0.968 |
SDG96695.1 | SDG97624.1 | SAMN04489796_1011056 | SAMN04489796_1011078 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Acetolactate synthase, large subunit. | 0.964 |
SDG96695.1 | SDH30025.1 | SAMN04489796_1011056 | SAMN04489796_102213 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Branched-chain amino acid aminotransferase. | 0.932 |
SDG96695.1 | SDH37277.1 | SAMN04489796_1011056 | SAMN04489796_102431 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Branched-chain amino acid aminotransferase. | 0.979 |
SDG96695.1 | ilvC | SAMN04489796_1011056 | SAMN04489796_1011076 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.744 |
SDG96695.1 | ilvD | SAMN04489796_1011056 | SAMN04489796_1011079 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.978 |
SDG96695.1 | leuB | SAMN04489796_1011056 | SAMN04489796_1011059 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.982 |
SDG96695.1 | leuC | SAMN04489796_1011056 | SAMN04489796_1011057 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.998 |
SDG96695.1 | leuD | SAMN04489796_1011056 | SAMN04489796_1011058 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.994 |
SDG97575.1 | SDG96695.1 | SAMN04489796_1011077 | SAMN04489796_1011056 | Acetolactate synthase, small subunit. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.968 |
SDG97575.1 | SDG97624.1 | SAMN04489796_1011077 | SAMN04489796_1011078 | Acetolactate synthase, small subunit. | Acetolactate synthase, large subunit. | 0.999 |
SDG97575.1 | SDH30025.1 | SAMN04489796_1011077 | SAMN04489796_102213 | Acetolactate synthase, small subunit. | Branched-chain amino acid aminotransferase. | 0.518 |
SDG97575.1 | SDH37277.1 | SAMN04489796_1011077 | SAMN04489796_102431 | Acetolactate synthase, small subunit. | Branched-chain amino acid aminotransferase. | 0.550 |
SDG97575.1 | ilvA | SAMN04489796_1011077 | SAMN04489796_1011075 | Acetolactate synthase, small subunit. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.954 |
SDG97575.1 | ilvC | SAMN04489796_1011077 | SAMN04489796_1011076 | Acetolactate synthase, small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.998 |
SDG97575.1 | ilvD | SAMN04489796_1011077 | SAMN04489796_1011079 | Acetolactate synthase, small subunit. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.972 |
SDG97575.1 | leuB | SAMN04489796_1011077 | SAMN04489796_1011059 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.984 |
SDG97575.1 | leuC | SAMN04489796_1011077 | SAMN04489796_1011057 | Acetolactate synthase, small subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.857 |
SDG97575.1 | leuD | SAMN04489796_1011077 | SAMN04489796_1011058 | Acetolactate synthase, small subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.884 |
SDG97624.1 | SDG96695.1 | SAMN04489796_1011078 | SAMN04489796_1011056 | Acetolactate synthase, large subunit. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.964 |