STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SHG17975.12-oxoglutarate dehydrogenase E1 component. (924 aa)    
Predicted Functional Partners:
SHG18001.1
2-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 0.999
SHH08567.1
2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase).
 0.999
SHG87064.1
Dihydrolipoamide dehydrogenase.
 
 0.993
SHH62016.1
Dihydrolipoamide dehydrogenase.
 
 0.993
sucC
succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
 0.992
sucD
succinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 
 0.991
SHG09215.1
Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase).
 0.990
SHH32347.1
Hypothetical protein.
    
 
 0.984
SHH32560.1
2-oxoisovalerate dehydrogenase E1 component.
   
 0.977
SHH76734.1
Pyruvate/2-oxoglutarate/acetoin dehydrogenase complex, dehydrogenase (E1) component.
   
 0.977
Your Current Organism:
Flavobacterium frigidimaris
NCBI taxonomy Id: 262320
Other names: Cytophaga sp. KUC-1, DSM 15937, F. frigidimaris, Flavobacterium frigidimaris Nogi et al. 2005, JCM 12218, strain KUC-1
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