STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (206 aa)    
Predicted Functional Partners:
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
 
 
 0.960
rpoZ
DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
  
  
 0.956
xpt
Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
  
 
 0.943
Exig_2211
TIGRFAM: pyruvate kinase; PFAM: PEP-utilising protein mobile region; Pyruvate kinase barrel; Pyruvate kinase alpha/beta; KEGG: bha:BH3163 pyruvate kinase; Belongs to the pyruvate kinase family.
 
 
 0.943
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
  
 
 0.940
ndk
Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
   
 0.927
Exig_1633
KEGG: tcx:Tcr_2138 guanylate kinase; PFAM: guanylate kinase; SMART: guanylate kinase/L-type calcium channel region.
  
  
 
0.924
Exig_2089
(p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
  
 
 0.921
Exig_0051
KEGG: gka:GK0061 hypoxanthine-guanine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
  
 0.920
Exig_0016
PFAM: deoxynucleoside kinase; KEGG: bce:BC0021 deoxyguanosine kinase.
     
 0.913
Your Current Organism:
Exiguobacterium sibiricum
NCBI taxonomy Id: 262543
Other names: E. sibiricum 255-15, Exiguobacterium sibiricum 255-15, Exiguobacterium sibiricum str. 255-15, Exiguobacterium sibiricum strain 255-15, Exiguobacterium sp. 255-15, Exiguobacterium strain 255-15
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