Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Score
Exig_2136Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (228 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
 0.999
Exig_2135
Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: oih:OB2066 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 
 0.998
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
  
 
 0.970
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.970
hemL2
TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: gtn:GTNG_2571 glutamate-1-semialdehyde 2,1-aminotransferase.
 
  
 0.952
Exig_1015
TIGRFAM: cytochrome c-type biogenesis protein CcsB; PFAM: cytochrome c assembly protein; KEGG: gka:GK2280 cytochrome c biogenesis protein.
 
  
 0.942
Exig_1014
PFAM: ResB family protein; KEGG: bld:BLi02460 ResB.
  
    0.792
hemL1
TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: bpu:BPUM_0825 glutamate-1-semialdehyde 2,1-aminomutase.
 
  
 0.791
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
  
 0.770
Exig_2022
PFAM: FAD dependent oxidoreductase; KEGG: mxa:MXAN_0202 amine oxidase, flavin-containing.
  
  
 0.724
Your Current Organism:
Exiguobacterium sibiricum
NCBI taxonomy Id: 262543
Other names: E. sibiricum 255-15, Exiguobacterium sibiricum 255-15, Exiguobacterium sibiricum str. 255-15, Exiguobacterium sibiricum strain 255-15, Exiguobacterium sp. 255-15, Exiguobacterium strain 255-15
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