node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SC1_00302 | SC1_00994 | SC1_00302 | SC1_00994 | Para-aminobenzoate synthase, aminase component. | Glutamate synthase [NADPH] large chain. | 0.666 |
SC1_00302 | SC1_01230 | SC1_00302 | SC1_01230 | Para-aminobenzoate synthase, aminase component. | Leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.483 |
SC1_00302 | SC1_01292 | SC1_00302 | SC1_01292 | Para-aminobenzoate synthase, aminase component. | Acetolactate synthase large subunit. | 0.830 |
SC1_00302 | SC1_03246 | SC1_00302 | SC1_03246 | Para-aminobenzoate synthase, aminase component. | Branched-chain amino acid aminotransferase. | 0.550 |
SC1_00302 | ilvC | SC1_00302 | SC1_01290 | Para-aminobenzoate synthase, aminase component. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.709 |
SC1_00302 | ilvD | SC1_00302 | SC1_01853 | Para-aminobenzoate synthase, aminase component. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.904 |
SC1_00302 | leuA | SC1_00302 | SC1_01261 | Para-aminobenzoate synthase, aminase component. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.886 |
SC1_00302 | leuB | SC1_00302 | SC1_02125 | Para-aminobenzoate synthase, aminase component. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.621 |
SC1_00302 | panB | SC1_00302 | SC1_00613 | Para-aminobenzoate synthase, aminase component. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.704 |
SC1_00994 | SC1_00302 | SC1_00994 | SC1_00302 | Glutamate synthase [NADPH] large chain. | Para-aminobenzoate synthase, aminase component. | 0.666 |
SC1_00994 | SC1_01230 | SC1_00994 | SC1_01230 | Glutamate synthase [NADPH] large chain. | Leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.999 |
SC1_00994 | SC1_01292 | SC1_00994 | SC1_01292 | Glutamate synthase [NADPH] large chain. | Acetolactate synthase large subunit. | 0.647 |
SC1_00994 | SC1_03246 | SC1_00994 | SC1_03246 | Glutamate synthase [NADPH] large chain. | Branched-chain amino acid aminotransferase. | 0.467 |
SC1_00994 | ilvC | SC1_00994 | SC1_01290 | Glutamate synthase [NADPH] large chain. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.784 |
SC1_00994 | ilvD | SC1_00994 | SC1_01853 | Glutamate synthase [NADPH] large chain. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.886 |
SC1_00994 | leuA | SC1_00994 | SC1_01261 | Glutamate synthase [NADPH] large chain. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.521 |
SC1_00994 | leuB | SC1_00994 | SC1_02125 | Glutamate synthase [NADPH] large chain. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.957 |
SC1_01230 | SC1_00302 | SC1_01230 | SC1_00302 | Leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Para-aminobenzoate synthase, aminase component. | 0.483 |
SC1_01230 | SC1_00994 | SC1_01230 | SC1_00994 | Leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glutamate synthase [NADPH] large chain. | 0.999 |
SC1_01230 | SC1_03246 | SC1_01230 | SC1_03246 | Leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Branched-chain amino acid aminotransferase. | 0.889 |