node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F933_01254 | F933_03183 | GCA_000931715_01237 | GCA_000931715_02241 | Unannotated protein; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. | Unannotated protein; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.509 |
F933_01254 | msrA | GCA_000931715_01237 | GCA_000931715_00192 | Unannotated protein; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. | Unannotated protein; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.843 |
F933_01668 | F933_03363 | GCA_000931715_01996 | GCA_000931715_00075 | Unannotated protein. | Unannotated protein. | 0.982 |
F933_01668 | msrA | GCA_000931715_01996 | GCA_000931715_00192 | Unannotated protein. | Unannotated protein; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.870 |
F933_01668 | msrB | GCA_000931715_01996 | GCA_000931715_02768 | Unannotated protein. | Unannotated protein; Belongs to the MsrB Met sulfoxide reductase family. | 0.870 |
F933_02321 | F933_02323 | GCA_000931715_00193 | GCA_000931715_00195 | Unannotated protein. | Unannotated protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.590 |
F933_02321 | msrA | GCA_000931715_00193 | GCA_000931715_00192 | Unannotated protein. | Unannotated protein; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.684 |
F933_02321 | thyA | GCA_000931715_00193 | GCA_000931715_00196 | Unannotated protein. | Unannotated protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.530 |
F933_02323 | F933_02321 | GCA_000931715_00195 | GCA_000931715_00193 | Unannotated protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Unannotated protein. | 0.590 |
F933_02323 | F933_03183 | GCA_000931715_00195 | GCA_000931715_02241 | Unannotated protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Unannotated protein; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.935 |
F933_02323 | msrA | GCA_000931715_00195 | GCA_000931715_00192 | Unannotated protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Unannotated protein; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.477 |
F933_02323 | thyA | GCA_000931715_00195 | GCA_000931715_00196 | Unannotated protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Unannotated protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
F933_03183 | F933_01254 | GCA_000931715_02241 | GCA_000931715_01237 | Unannotated protein; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Unannotated protein; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. | 0.509 |
F933_03183 | F933_02323 | GCA_000931715_02241 | GCA_000931715_00195 | Unannotated protein; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Unannotated protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.935 |
F933_03183 | msrA | GCA_000931715_02241 | GCA_000931715_00192 | Unannotated protein; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Unannotated protein; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.446 |
F933_03183 | thyA | GCA_000931715_02241 | GCA_000931715_00196 | Unannotated protein; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Unannotated protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.613 |
F933_03363 | F933_01668 | GCA_000931715_00075 | GCA_000931715_01996 | Unannotated protein. | Unannotated protein. | 0.982 |
F933_03363 | msrA | GCA_000931715_00075 | GCA_000931715_00192 | Unannotated protein. | Unannotated protein; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.989 |
F933_03363 | msrB | GCA_000931715_00075 | GCA_000931715_02768 | Unannotated protein. | Unannotated protein; Belongs to the MsrB Met sulfoxide reductase family. | 0.783 |
macB | msrA | GCA_000931715_01247 | GCA_000931715_00192 | Unannotated protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | Unannotated protein; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.418 |