STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (198 aa)    
Predicted Functional Partners:
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
  
 
 0.973
hpt
Hypoxanthine-guanine phosphoribosyltransferase; Identified by sequence similarity; putative; ORF located using Blastx;COG0634; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
     
 0.956
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
  
 
 0.925
pyk
Pyruvate kinase; Identified by sequence similarity; putative; ORF located using Blastx;COG0469; Belongs to the pyruvate kinase family.
  
 
 0.922
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
   
 
 0.918
nrdE
Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
    
 0.910
nrdF
Ribonucleoside-diphosphate reductase beta chain; Identified by sequence similarity; putative; ORF located using Blastx;COG0208.
     
 0.909
rpe
Ribulose-phosphate 3-epimerase; Identified by sequence similarity; putative; ORF located using Glimmer;Blastx;COG0036.
  
 
 0.855
prpC
Protein phosphatase; Identified by sequence similarity; putative; ORF located using Glimmer;Blastx;COG0631.
   
   0.837
dnaK
Chaperone protein dnaK - heat shock protein 70; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.837
Your Current Organism:
Mycoplasma synoviae
NCBI taxonomy Id: 262723
Other names: M. synoviae 53, Mycoplasma synoviae 53, Mycoplasma synoviae str. 53, Mycoplasma synoviae strain 53
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