| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MS53_0310 | glyA | MS53_0310 | MS53_0305 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.520 |
| MS53_0310 | leuS | MS53_0310 | MS53_0311 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx. | leucyl-tRNA synthetase; Identified by sequence similarity; putative; ORF located using Blastx;COG0495; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.814 |
| MS53_0310 | lon | MS53_0310 | MS53_0312 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx. | Heat shock ATP-dependent protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity). | 0.711 |
| MS53_0310 | upp | MS53_0310 | MS53_0309 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx. | Uracil phosphoribosyltransferase; Identified by sequence similarity; putative; ORF located using Blastx;COG0035; Belongs to the UPRTase family. | 0.818 |
| dnaK | ftsH | MS53_0351 | MS53_0614 | Chaperone protein dnaK - heat shock protein 70; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | 0.665 |
| dnaK | glyA | MS53_0351 | MS53_0305 | Chaperone protein dnaK - heat shock protein 70; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.481 |
| dnaK | grpE | MS53_0351 | MS53_0352 | Chaperone protein dnaK - heat shock protein 70; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.997 |
| dnaK | ileS | MS53_0351 | MS53_0558 | Chaperone protein dnaK - heat shock protein 70; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Ile-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. | 0.524 |
| dnaK | ldh | MS53_0351 | MS53_0461 | Chaperone protein dnaK - heat shock protein 70; Acts as a chaperone; Belongs to the heat shock protein 70 family. | L-lactate dehydrogenase; Identified by sequence similarity; putative; ORF located using Blastx;COG0039; Belongs to the LDH/MDH superfamily. | 0.792 |
| dnaK | lon | MS53_0351 | MS53_0312 | Chaperone protein dnaK - heat shock protein 70; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Heat shock ATP-dependent protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity). | 0.844 |
| dnaK | rpsB | MS53_0351 | MS53_0413 | Chaperone protein dnaK - heat shock protein 70; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 30S ribosomal protein S2; Identified by sequence similarity; putative; ORF located using Blastx;COG0052; Belongs to the universal ribosomal protein uS2 family. | 0.878 |
| ftsH | dnaK | MS53_0614 | MS53_0351 | Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | Chaperone protein dnaK - heat shock protein 70; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.665 |
| ftsH | grpE | MS53_0614 | MS53_0352 | Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.504 |
| ftsH | lon | MS53_0614 | MS53_0312 | Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | Heat shock ATP-dependent protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity). | 0.773 |
| ftsH | rpsB | MS53_0614 | MS53_0413 | Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | 30S ribosomal protein S2; Identified by sequence similarity; putative; ORF located using Blastx;COG0052; Belongs to the universal ribosomal protein uS2 family. | 0.767 |
| glyA | MS53_0310 | MS53_0305 | MS53_0310 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx. | 0.520 |
| glyA | dnaK | MS53_0305 | MS53_0351 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Chaperone protein dnaK - heat shock protein 70; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.481 |
| glyA | leuS | MS53_0305 | MS53_0311 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | leucyl-tRNA synthetase; Identified by sequence similarity; putative; ORF located using Blastx;COG0495; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.671 |
| glyA | lon | MS53_0305 | MS53_0312 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Heat shock ATP-dependent protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity). | 0.825 |
| glyA | upp | MS53_0305 | MS53_0309 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Uracil phosphoribosyltransferase; Identified by sequence similarity; putative; ORF located using Blastx;COG0035; Belongs to the UPRTase family. | 0.772 |
