| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MS53_0664 | rpiB | MS53_0664 | MS53_0392 | Putative GTP-binding protein; Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. | Ribose 5-phosphate isomerase B; Identified by sequence similarity; putative; ORF located using Glimmer;Blastx;COG0698. | 0.730 |
| cls | glyA | MS53_0393 | MS53_0305 | Cardiolipin synthetase; Identified by sequence similarity; putative; ORF located using Blastx;COG1502. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.584 |
| cls | ptsH | MS53_0393 | MS53_0394 | Cardiolipin synthetase; Identified by sequence similarity; putative; ORF located using Blastx;COG1502. | Phophocarrier protein HPr; Identified by sequence similarity; putative; ORF located using Blastx;COG1925. | 0.654 |
| cls | rpiB | MS53_0393 | MS53_0392 | Cardiolipin synthetase; Identified by sequence similarity; putative; ORF located using Blastx;COG1502. | Ribose 5-phosphate isomerase B; Identified by sequence similarity; putative; ORF located using Glimmer;Blastx;COG0698. | 0.779 |
| deoB | prsA | MS53_0083 | MS53_0150 | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. | Ribose-phosphate pyrophosphokinase; Identified by sequence similarity; putative; ORF located using Blastx;COG0462. | 0.910 |
| deoB | rpe | MS53_0083 | MS53_0119 | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. | Ribulose-phosphate 3-epimerase; Identified by sequence similarity; putative; ORF located using Glimmer;Blastx;COG0036. | 0.463 |
| deoB | rpiB | MS53_0083 | MS53_0392 | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. | Ribose 5-phosphate isomerase B; Identified by sequence similarity; putative; ORF located using Glimmer;Blastx;COG0698. | 0.934 |
| deoB | tktA | MS53_0083 | MS53_0181 | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. | Transketolase; Identified by sequence similarity; putative; ORF located using Blastx;COG0021; Belongs to the transketolase family. | 0.915 |
| glyA | cls | MS53_0305 | MS53_0393 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Cardiolipin synthetase; Identified by sequence similarity; putative; ORF located using Blastx;COG1502. | 0.584 |
| glyA | prsA | MS53_0305 | MS53_0150 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Ribose-phosphate pyrophosphokinase; Identified by sequence similarity; putative; ORF located using Blastx;COG0462. | 0.402 |
| glyA | rpiB | MS53_0305 | MS53_0392 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Ribose 5-phosphate isomerase B; Identified by sequence similarity; putative; ORF located using Glimmer;Blastx;COG0698. | 0.923 |
| glyA | upp | MS53_0305 | MS53_0309 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Uracil phosphoribosyltransferase; Identified by sequence similarity; putative; ORF located using Blastx;COG0035; Belongs to the UPRTase family. | 0.891 |
| prsA | deoB | MS53_0150 | MS53_0083 | Ribose-phosphate pyrophosphokinase; Identified by sequence similarity; putative; ORF located using Blastx;COG0462. | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. | 0.910 |
| prsA | glyA | MS53_0150 | MS53_0305 | Ribose-phosphate pyrophosphokinase; Identified by sequence similarity; putative; ORF located using Blastx;COG0462. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.402 |
| prsA | ptsG | MS53_0150 | MS53_0147 | Ribose-phosphate pyrophosphokinase; Identified by sequence similarity; putative; ORF located using Blastx;COG0462. | PTS system, glucose-specific IIABC component; Identified by sequence similarity; putative; ORF located using Blastx;COG1263;TC:4.A.1.1.2. | 0.838 |
| prsA | rpe | MS53_0150 | MS53_0119 | Ribose-phosphate pyrophosphokinase; Identified by sequence similarity; putative; ORF located using Blastx;COG0462. | Ribulose-phosphate 3-epimerase; Identified by sequence similarity; putative; ORF located using Glimmer;Blastx;COG0036. | 0.560 |
| prsA | rpiB | MS53_0150 | MS53_0392 | Ribose-phosphate pyrophosphokinase; Identified by sequence similarity; putative; ORF located using Blastx;COG0462. | Ribose 5-phosphate isomerase B; Identified by sequence similarity; putative; ORF located using Glimmer;Blastx;COG0698. | 0.947 |
| prsA | tktA | MS53_0150 | MS53_0181 | Ribose-phosphate pyrophosphokinase; Identified by sequence similarity; putative; ORF located using Blastx;COG0462. | Transketolase; Identified by sequence similarity; putative; ORF located using Blastx;COG0021; Belongs to the transketolase family. | 0.947 |
| ptsG | prsA | MS53_0147 | MS53_0150 | PTS system, glucose-specific IIABC component; Identified by sequence similarity; putative; ORF located using Blastx;COG1263;TC:4.A.1.1.2. | Ribose-phosphate pyrophosphokinase; Identified by sequence similarity; putative; ORF located using Blastx;COG0462. | 0.838 |
| ptsG | ptsH | MS53_0147 | MS53_0394 | PTS system, glucose-specific IIABC component; Identified by sequence similarity; putative; ORF located using Blastx;COG1263;TC:4.A.1.1.2. | Phophocarrier protein HPr; Identified by sequence similarity; putative; ORF located using Blastx;COG1925. | 0.997 |