node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MS53_0395 | comEB | MS53_0395 | MS53_0396 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx. | Deoxycytidylate deaminase fusion protein; Identified by sequence similarity; putative; ORF located using Blastx;COG2131. | 0.664 |
MS53_0395 | folA | MS53_0395 | MS53_0397 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx. | Dihydrofolate reductase; Identified by sequence similarity; putative; ORF located using Blastx;COG0262; Belongs to the dihydrofolate reductase family. | 0.664 |
MS53_0395 | thyA | MS53_0395 | MS53_0398 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.664 |
comEB | MS53_0395 | MS53_0396 | MS53_0395 | Deoxycytidylate deaminase fusion protein; Identified by sequence similarity; putative; ORF located using Blastx;COG2131. | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx. | 0.664 |
comEB | folA | MS53_0396 | MS53_0397 | Deoxycytidylate deaminase fusion protein; Identified by sequence similarity; putative; ORF located using Blastx;COG2131. | Dihydrofolate reductase; Identified by sequence similarity; putative; ORF located using Blastx;COG0262; Belongs to the dihydrofolate reductase family. | 0.925 |
comEB | nrdE | MS53_0396 | MS53_0401 | Deoxycytidylate deaminase fusion protein; Identified by sequence similarity; putative; ORF located using Blastx;COG2131. | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.446 |
comEB | nrdF | MS53_0396 | MS53_0399 | Deoxycytidylate deaminase fusion protein; Identified by sequence similarity; putative; ORF located using Blastx;COG2131. | Ribonucleoside-diphosphate reductase beta chain; Identified by sequence similarity; putative; ORF located using Blastx;COG0208. | 0.432 |
comEB | tdk | MS53_0396 | MS53_0521 | Deoxycytidylate deaminase fusion protein; Identified by sequence similarity; putative; ORF located using Blastx;COG2131. | Thymidine kinase; Identified by sequence similarity; putative; ORF located using Glimmer;Blastx;COG1435. | 0.930 |
comEB | thyA | MS53_0396 | MS53_0398 | Deoxycytidylate deaminase fusion protein; Identified by sequence similarity; putative; ORF located using Blastx;COG2131. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.985 |
comEB | tmk | MS53_0396 | MS53_0052 | Deoxycytidylate deaminase fusion protein; Identified by sequence similarity; putative; ORF located using Blastx;COG2131. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.928 |
dnaN | glyA | MS53_0002 | MS53_0305 | DNA polymerase III beta subunit; Identified by sequence similarity; putative; ORF located using Blastx;COG0592. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.468 |
dnaN | nrdE | MS53_0002 | MS53_0401 | DNA polymerase III beta subunit; Identified by sequence similarity; putative; ORF located using Blastx;COG0592. | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.800 |
dnaN | thyA | MS53_0002 | MS53_0398 | DNA polymerase III beta subunit; Identified by sequence similarity; putative; ORF located using Blastx;COG0592. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.781 |
folA | MS53_0395 | MS53_0397 | MS53_0395 | Dihydrofolate reductase; Identified by sequence similarity; putative; ORF located using Blastx;COG0262; Belongs to the dihydrofolate reductase family. | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx. | 0.664 |
folA | comEB | MS53_0397 | MS53_0396 | Dihydrofolate reductase; Identified by sequence similarity; putative; ORF located using Blastx;COG0262; Belongs to the dihydrofolate reductase family. | Deoxycytidylate deaminase fusion protein; Identified by sequence similarity; putative; ORF located using Blastx;COG2131. | 0.925 |
folA | glyA | MS53_0397 | MS53_0305 | Dihydrofolate reductase; Identified by sequence similarity; putative; ORF located using Blastx;COG0262; Belongs to the dihydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.935 |
folA | nrdE | MS53_0397 | MS53_0401 | Dihydrofolate reductase; Identified by sequence similarity; putative; ORF located using Blastx;COG0262; Belongs to the dihydrofolate reductase family. | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.534 |
folA | nrdF | MS53_0397 | MS53_0399 | Dihydrofolate reductase; Identified by sequence similarity; putative; ORF located using Blastx;COG0262; Belongs to the dihydrofolate reductase family. | Ribonucleoside-diphosphate reductase beta chain; Identified by sequence similarity; putative; ORF located using Blastx;COG0208. | 0.548 |
folA | thyA | MS53_0397 | MS53_0398 | Dihydrofolate reductase; Identified by sequence similarity; putative; ORF located using Blastx;COG0262; Belongs to the dihydrofolate reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.996 |
folD | glyA | MS53_0297 | MS53_0305 | Methylenetetrahydrofolate dehydrogenase / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.975 |