Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nrdERibonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (724 aa)    
Predicted Functional Partners:
nrdF
Ribonucleoside-diphosphate reductase beta chain; Identified by sequence similarity; putative; ORF located using Blastx;COG0208.
 0.999
nrdI
NrdI protein; Probably involved in ribonucleotide reductase function.
  
  
 0.960
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
 
 0.937
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
   
 0.924
cmk
Cytidylate kinase; Identified by sequence similarity; putative; ORF located using Blastx;COG0283.
  
 
 0.923
MS53_0528
Identified by sequence similarity; putative; ORF located using Blastx;COG0258.
  
 
 0.904
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
    
 0.902
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.875
trxA
Putative thioredoxin; Identified by sequence similarity; putative; ORF located using Blastx;COG0526.
  
 
 0.800
trxM
Thioredoxin; Identified by sequence similarity; putative; ORF located using Blastx;COG0526; Belongs to the thioredoxin family.
  
 
 0.800
Your Current Organism:
Mycoplasma synoviae
NCBI taxonomy Id: 262723
Other names: M. synoviae 53, Mycoplasma synoviae 53, Mycoplasma synoviae str. 53, Mycoplasma synoviae strain 53
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