Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
dnaBReplicative DNA helicase; Identified by sequence similarity; putative; ORF located using Blastx;COG0305. (508 aa)    
Predicted Functional Partners:
dnaG
DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
 
 0.925
MS53_0525
Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx.
  
 
 0.910
rplI
50S ribosomal protein L9; Binds to the 23S rRNA.
  
  
 0.865
dnaA
Chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
 
 
 
 0.858
MS53_0427
Putative DHH subfamily 1 protein; Identified by sequence similarity; putative; ORF located using Blastx;COG3887.
  
    0.834
MS53_0428
Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx.
       0.773
hlyC
Identified by sequence similarity; putative; ORF located using Blastx;COG1253;TC:9.B.37.2.1.
       0.755
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.693
MS53_0528
Identified by sequence similarity; putative; ORF located using Blastx;COG0258.
  
  
 0.689
MS53_0429
Hypothetical protein.
       0.639
Your Current Organism:
Mycoplasma synoviae
NCBI taxonomy Id: 262723
Other names: M. synoviae 53, Mycoplasma synoviae 53, Mycoplasma synoviae str. 53, Mycoplasma synoviae strain 53
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