Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
thiIThiamine biosynthesis protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (376 aa)    
Predicted Functional Partners:
MS53_0503
Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx;COG0561.
       0.778
MS53_0504
Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx.
       0.773
hemK
Protoporphirogen oxidase HemK; Identified by sequence similarity; putative; ORF located using Blastx;COG2890.
      
 0.505
nfo
Endonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
   
  
 0.504
pknB
Serine/threonine-protein kinase; Identified by sequence similarity; putative; ORF located using Blastx;COG0515.
      
 0.482
rpmH
50S ribosomal protein L34; Identified by sequence similarity; putative; ORF located using Blastx;COG0230; Belongs to the bacterial ribosomal protein bL34 family.
      
 0.470
MS53_0501
Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx.
       0.454
MS53_0502
Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx.
       0.454
potB
Spermidine/putrescine ABC transporter permease protein PotB; Identified by sequence similarity; putative; ORF located using Blastx;COG1176;TC:3.A.1.11.1.
  
  
 0.454
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
     
 0.446
Your Current Organism:
Mycoplasma synoviae
NCBI taxonomy Id: 262723
Other names: M. synoviae 53, Mycoplasma synoviae 53, Mycoplasma synoviae str. 53, Mycoplasma synoviae strain 53
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