Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ligDNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (697 aa)    
Predicted Functional Partners:
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
 
 0.815
MS53_0569
Putative tRNA/rRNA methyltransferase; Identified by sequence similarity; putative; ORF located using Blastx;COG0566.
  
    0.812
leuS
leucyl-tRNA synthetase; Identified by sequence similarity; putative; ORF located using Blastx;COG0495; Belongs to the class-I aminoacyl-tRNA synthetase family.
   
 
 0.776
MS53_0568
Putative tRNA/rRNA methyltransferase; Could methylate the ribose at the nucleotide 34 wobble position in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
       0.773
MS53_0570
Hypothetical protein.
       0.773
MS53_0528
Identified by sequence similarity; putative; ORF located using Blastx;COG0258.
 
   
 0.738
pcrA
Atp-dependent helicase; Identified by sequence similarity; putative; ORF located using Blastx;COG0210.
  
  
 0.680
dnaE
DNA polymerase III alpha subunit; Identified by sequence similarity; putative; ORF located using Blastx;COG0587.
 
   
 0.675
ribF
Riboflavin kinase / FMN adenylyltransferase; Identified by sequence similarity; putative; ORF located using Blastx;COG0196.
  
    0.648
truB
tRNA pseudouridine synthase B; Identified by sequence similarity; putative; ORF located using Blastx;COG0130; Belongs to the pseudouridine synthase TruB family.
  
    0.587
Your Current Organism:
Mycoplasma synoviae
NCBI taxonomy Id: 262723
Other names: M. synoviae 53, Mycoplasma synoviae 53, Mycoplasma synoviae str. 53, Mycoplasma synoviae strain 53
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.