STRING protein interaction network
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
protein homology
Your Input:
Gene Fusion
rpsL30S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy (134 aa)    
Predicted Functional Partners:
30S ribosomal protein S2; Spans the head-body hinge region of the 30S subunit. Is loosely associated with the 30S subunit (By similarity)
30S ribosomal protein S16; Binds to the lower part of the body of the 30S subunit, where it stabilizes two of its domains
30S ribosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA
30S ribosomal protein S9; Part of the top of the head of the 30S subunit. The C- terminal region penetrates the head emerging in the P-site where it contacts tRNA (By similarity)
50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
annotation not available
DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the body and platform of the 30S subunit
30S ribosomal protein S11; Located on the upper part of the platform of the 30S subunit, where it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P- sites (By similarity)
Your Current Organism:
Thermus thermophilus HB27
NCBI taxonomy Id: 262724
Other names: T. thermophilus HB27, Thermus thermophilus HB27, Thermus thermophilus str. HB27, Thermus thermophilus strain HB27
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