node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PAM_072 | dut | PAM_072 | PAM_164 | Hypothetical protein; Possible pseudogene of thymidylate kinase; identified by sequence similarity; putative. | dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.947 |
PAM_072 | tdk | PAM_072 | PAM_104 | Hypothetical protein; Possible pseudogene of thymidylate kinase; identified by sequence similarity; putative. | Thymidine kinase; Identified by sequence similarity; putative. | 0.946 |
PAM_072 | thyA | PAM_072 | PAM_293 | Hypothetical protein; Possible pseudogene of thymidylate kinase; identified by sequence similarity; putative. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.946 |
PAM_390 | dut | PAM_390 | PAM_164 | Hypothetical protein; Possible pseudogene of thymidylate kinase; identified by sequence similarity; putative. | dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.947 |
PAM_390 | tdk | PAM_390 | PAM_104 | Hypothetical protein; Possible pseudogene of thymidylate kinase; identified by sequence similarity; putative. | Thymidine kinase; Identified by sequence similarity; putative. | 0.946 |
PAM_390 | thyA | PAM_390 | PAM_293 | Hypothetical protein; Possible pseudogene of thymidylate kinase; identified by sequence similarity; putative. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.946 |
PAM_544 | dut | PAM_544 | PAM_164 | Hypothetical protein; Possible pseudogene of thymidylate kinase; identified by sequence similarity; putative. | dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.947 |
PAM_544 | tdk | PAM_544 | PAM_104 | Hypothetical protein; Possible pseudogene of thymidylate kinase; identified by sequence similarity; putative. | Thymidine kinase; Identified by sequence similarity; putative. | 0.946 |
PAM_544 | thyA | PAM_544 | PAM_293 | Hypothetical protein; Possible pseudogene of thymidylate kinase; identified by sequence similarity; putative. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.946 |
PAM_552 | dut | PAM_552 | PAM_164 | Hypothetical protein; Possible pseudogene of thymidylate kinase; identified by sequence similarity; putative. | dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.947 |
PAM_552 | tdk | PAM_552 | PAM_104 | Hypothetical protein; Possible pseudogene of thymidylate kinase; identified by sequence similarity; putative. | Thymidine kinase; Identified by sequence similarity; putative. | 0.947 |
PAM_552 | thyA | PAM_552 | PAM_293 | Hypothetical protein; Possible pseudogene of thymidylate kinase; identified by sequence similarity; putative. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.947 |
dut | PAM_072 | PAM_164 | PAM_072 | dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Hypothetical protein; Possible pseudogene of thymidylate kinase; identified by sequence similarity; putative. | 0.947 |
dut | PAM_390 | PAM_164 | PAM_390 | dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Hypothetical protein; Possible pseudogene of thymidylate kinase; identified by sequence similarity; putative. | 0.947 |
dut | PAM_544 | PAM_164 | PAM_544 | dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Hypothetical protein; Possible pseudogene of thymidylate kinase; identified by sequence similarity; putative. | 0.947 |
dut | PAM_552 | PAM_164 | PAM_552 | dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Hypothetical protein; Possible pseudogene of thymidylate kinase; identified by sequence similarity; putative. | 0.947 |
dut | tdk | PAM_164 | PAM_104 | dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidine kinase; Identified by sequence similarity; putative. | 0.984 |
dut | thyA | PAM_164 | PAM_293 | dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.990 |
dut | tmk | PAM_164 | PAM_230 | dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.947 |
dut | tmk-2 | PAM_164 | PAM_344 | dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.947 |