| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PAM_502 | PAM_503 | PAM_502 | PAM_503 | Conserved hypothetical protein; Identified by sequence similarity; putative. | Hypothetical protein; Possible pseudogene of DNA-directed RNA polymerase specialized sigma subunit (FliA); identified by sequence. | 0.469 |
| PAM_503 | PAM_502 | PAM_503 | PAM_502 | Hypothetical protein; Possible pseudogene of DNA-directed RNA polymerase specialized sigma subunit (FliA); identified by sequence. | Conserved hypothetical protein; Identified by sequence similarity; putative. | 0.469 |
| PAM_503 | gyrA | PAM_503 | PAM_499 | Hypothetical protein; Possible pseudogene of DNA-directed RNA polymerase specialized sigma subunit (FliA); identified by sequence. | DNA gyrase alpha subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.456 |
| PAM_503 | gyrB | PAM_503 | PAM_498 | Hypothetical protein; Possible pseudogene of DNA-directed RNA polymerase specialized sigma subunit (FliA); identified by sequence. | DNA gyrase beta subunit; Identified by sequence similarity; putative. | 0.439 |
| PAM_503 | rplN | PAM_503 | PAM_210 | Hypothetical protein; Possible pseudogene of DNA-directed RNA polymerase specialized sigma subunit (FliA); identified by sequence. | Ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. | 0.507 |
| PAM_503 | rpoA | PAM_503 | PAM_227 | Hypothetical protein; Possible pseudogene of DNA-directed RNA polymerase specialized sigma subunit (FliA); identified by sequence. | DNA-directed RNA polymerase alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.727 |
| PAM_503 | rpoB | PAM_503 | PAM_260 | Hypothetical protein; Possible pseudogene of DNA-directed RNA polymerase specialized sigma subunit (FliA); identified by sequence. | DNA-directed RNA polymerase beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.727 |
| PAM_503 | rpoC | PAM_503 | PAM_261 | Hypothetical protein; Possible pseudogene of DNA-directed RNA polymerase specialized sigma subunit (FliA); identified by sequence. | DNA-directed RNA polymerase beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.728 |
| PAM_503 | rpoZ | PAM_503 | PAM_736 | Hypothetical protein; Possible pseudogene of DNA-directed RNA polymerase specialized sigma subunit (FliA); identified by sequence. | DNA-directed RNA polymerase subunit K/omega; Identified by sequence similarity; putative. | 0.764 |
| PAM_503 | rpsO | PAM_503 | PAM_136 | Hypothetical protein; Possible pseudogene of DNA-directed RNA polymerase specialized sigma subunit (FliA); identified by sequence. | Ribosomal protein S15P/S13E; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. | 0.576 |
| PAM_503 | trxA | PAM_503 | PAM_236 | Hypothetical protein; Possible pseudogene of DNA-directed RNA polymerase specialized sigma subunit (FliA); identified by sequence. | Thioredoxin; Identified by sequence similarity; putative. | 0.611 |
| gyrA | PAM_503 | PAM_499 | PAM_503 | DNA gyrase alpha subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Hypothetical protein; Possible pseudogene of DNA-directed RNA polymerase specialized sigma subunit (FliA); identified by sequence. | 0.456 |
| gyrA | gyrB | PAM_499 | PAM_498 | DNA gyrase alpha subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA gyrase beta subunit; Identified by sequence similarity; putative. | 0.999 |
| gyrA | rplN | PAM_499 | PAM_210 | DNA gyrase alpha subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. | 0.426 |
| gyrA | rpoA | PAM_499 | PAM_227 | DNA gyrase alpha subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA-directed RNA polymerase alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.711 |
| gyrA | rpoB | PAM_499 | PAM_260 | DNA gyrase alpha subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA-directed RNA polymerase beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.690 |
| gyrA | rpoC | PAM_499 | PAM_261 | DNA gyrase alpha subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA-directed RNA polymerase beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.524 |
| gyrA | rpoZ | PAM_499 | PAM_736 | DNA gyrase alpha subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA-directed RNA polymerase subunit K/omega; Identified by sequence similarity; putative. | 0.575 |
| gyrA | rpsO | PAM_499 | PAM_136 | DNA gyrase alpha subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Ribosomal protein S15P/S13E; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. | 0.829 |
| gyrA | trxA | PAM_499 | PAM_236 | DNA gyrase alpha subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Thioredoxin; Identified by sequence similarity; putative. | 0.617 |