node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PAM_637 | PAM_638 | PAM_637 | PAM_638 | Conserved hypothetical protein; Identified by sequence similarity; putative; predicted hydrolase of the metallo-beta-lactamase. | Hypothetical protein; Identified by Glimmer2. | 0.547 |
PAM_637 | infA | PAM_637 | PAM_223 | Conserved hypothetical protein; Identified by sequence similarity; putative; predicted hydrolase of the metallo-beta-lactamase. | Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. | 0.803 |
PAM_637 | rnj | PAM_637 | PAM_633 | Conserved hypothetical protein; Identified by sequence similarity; putative; predicted hydrolase of the metallo-beta-lactamase. | Conserved hypothetical protein; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. | 0.958 |
PAM_637 | rnpA | PAM_637 | PAM_248 | Conserved hypothetical protein; Identified by sequence similarity; putative; predicted hydrolase of the metallo-beta-lactamase. | Ribonuclease P; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | 0.617 |
PAM_637 | rny | PAM_637 | PAM_272 | Conserved hypothetical protein; Identified by sequence similarity; putative; predicted hydrolase of the metallo-beta-lactamase. | Conserved hypothetical protein; Endoribonuclease that initiates mRNA decay. Belongs to the RNase Y family. | 0.747 |
PAM_637 | rplI | PAM_637 | PAM_012 | Conserved hypothetical protein; Identified by sequence similarity; putative; predicted hydrolase of the metallo-beta-lactamase. | Exopolyphosphatase-related protein; Binds to the 23S rRNA. | 0.620 |
PAM_637 | rplP | PAM_637 | PAM_207 | Conserved hypothetical protein; Identified by sequence similarity; putative; predicted hydrolase of the metallo-beta-lactamase. | Ribosomal protein L16/L10E; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. | 0.668 |
PAM_637 | rplW | PAM_637 | PAM_202 | Conserved hypothetical protein; Identified by sequence similarity; putative; predicted hydrolase of the metallo-beta-lactamase. | Ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. | 0.584 |
PAM_637 | rpoB | PAM_637 | PAM_260 | Conserved hypothetical protein; Identified by sequence similarity; putative; predicted hydrolase of the metallo-beta-lactamase. | DNA-directed RNA polymerase beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.695 |
PAM_637 | topA | PAM_637 | PAM_279 | Conserved hypothetical protein; Identified by sequence similarity; putative; predicted hydrolase of the metallo-beta-lactamase. | Topoisomerase IA; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA superco [...] | 0.676 |
PAM_638 | PAM_637 | PAM_638 | PAM_637 | Hypothetical protein; Identified by Glimmer2. | Conserved hypothetical protein; Identified by sequence similarity; putative; predicted hydrolase of the metallo-beta-lactamase. | 0.547 |
infA | PAM_637 | PAM_223 | PAM_637 | Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. | Conserved hypothetical protein; Identified by sequence similarity; putative; predicted hydrolase of the metallo-beta-lactamase. | 0.803 |
infA | rnj | PAM_223 | PAM_633 | Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. | Conserved hypothetical protein; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. | 0.803 |
infA | rnpA | PAM_223 | PAM_248 | Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. | Ribonuclease P; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | 0.731 |
infA | rplI | PAM_223 | PAM_012 | Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. | Exopolyphosphatase-related protein; Binds to the 23S rRNA. | 0.728 |
infA | rplP | PAM_223 | PAM_207 | Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. | Ribosomal protein L16/L10E; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. | 0.989 |
infA | rplW | PAM_223 | PAM_202 | Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. | Ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. | 0.980 |
infA | rpoB | PAM_223 | PAM_260 | Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. | DNA-directed RNA polymerase beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.795 |
infA | topA | PAM_223 | PAM_279 | Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. | Topoisomerase IA; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA superco [...] | 0.588 |
rnj | PAM_637 | PAM_633 | PAM_637 | Conserved hypothetical protein; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. | Conserved hypothetical protein; Identified by sequence similarity; putative; predicted hydrolase of the metallo-beta-lactamase. | 0.958 |