| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PAM_609 | dnaA | PAM_609 | PAM_001 | Conserved hypothetical protein; Identified by sequence similarity; putative. | Chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | 0.492 |
| PAM_609 | dnaB-8 | PAM_609 | PAM_673 | Conserved hypothetical protein; Identified by sequence similarity; putative. | Replication initiation/membrane attachment; Identified by sequence similarity; putative. | 0.710 |
| PAM_609 | dnaC | PAM_609 | PAM_672 | Conserved hypothetical protein; Identified by sequence similarity; putative. | DNA replication protein; Identified by sequence similarity; putative. | 0.715 |
| PAM_609 | polA | PAM_609 | PAM_675 | Conserved hypothetical protein; Identified by sequence similarity; putative. | DNA polymerase I; Identified by sequence similarity; putative. | 0.562 |
| PAM_609 | rplI | PAM_609 | PAM_012 | Conserved hypothetical protein; Identified by sequence similarity; putative. | Exopolyphosphatase-related protein; Binds to the 23S rRNA. | 0.585 |
| dnaA | PAM_609 | PAM_001 | PAM_609 | Chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | Conserved hypothetical protein; Identified by sequence similarity; putative. | 0.492 |
| dnaA | dnaB-8 | PAM_001 | PAM_673 | Chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | Replication initiation/membrane attachment; Identified by sequence similarity; putative. | 0.486 |
| dnaA | dnaC | PAM_001 | PAM_672 | Chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | DNA replication protein; Identified by sequence similarity; putative. | 0.731 |
| dnaA | ffh | PAM_001 | PAM_678 | Chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | Signal recognition particle GTPase; Identified by sequence similarity; putative. | 0.483 |
| dnaA | holA | PAM_001 | PAM_016 | Chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | DNA polymerase III delta subunit; Identified by sequence similarity; putative. | 0.423 |
| dnaA | holB | PAM_001 | PAM_231 | Chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | DNA polymerase III, delta prime subunit; Identified by sequence similarity; putative. | 0.483 |
| dnaA | nei | PAM_001 | PAM_674 | Chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.427 |
| dnaA | polA | PAM_001 | PAM_675 | Chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | DNA polymerase I; Identified by sequence similarity; putative. | 0.695 |
| dnaA | rplI | PAM_001 | PAM_012 | Chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | Exopolyphosphatase-related protein; Binds to the 23S rRNA. | 0.563 |
| dnaB-8 | PAM_609 | PAM_673 | PAM_609 | Replication initiation/membrane attachment; Identified by sequence similarity; putative. | Conserved hypothetical protein; Identified by sequence similarity; putative. | 0.710 |
| dnaB-8 | dnaA | PAM_673 | PAM_001 | Replication initiation/membrane attachment; Identified by sequence similarity; putative. | Chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | 0.486 |
| dnaB-8 | dnaC | PAM_673 | PAM_672 | Replication initiation/membrane attachment; Identified by sequence similarity; putative. | DNA replication protein; Identified by sequence similarity; putative. | 0.949 |
| dnaB-8 | exo | PAM_673 | PAM_676 | Replication initiation/membrane attachment; Identified by sequence similarity; putative. | 5'-3' exonuclease; Identified by sequence similarity; putative. | 0.570 |
| dnaB-8 | ffh | PAM_673 | PAM_678 | Replication initiation/membrane attachment; Identified by sequence similarity; putative. | Signal recognition particle GTPase; Identified by sequence similarity; putative. | 0.513 |
| dnaB-8 | holA | PAM_673 | PAM_016 | Replication initiation/membrane attachment; Identified by sequence similarity; putative. | DNA polymerase III delta subunit; Identified by sequence similarity; putative. | 0.620 |