| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PTO0165 | PTO0478 | PTO0165 | PTO0478 | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase. | Diphosphomevalonate decarboxylase; Catalyzes the ATP-independent decarboxylation of (R)- mevalonate 3,5-bisphosphate to isopentenyl phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3- phosphate rather than mevalonate 5-phosphate. Shows no detectable decarboxylase activity on mevalonate, mevalonate 3-phosphate, mevalonate 5-phosphate or mevalonate 5-pyrophosphate. | 0.766 |
| PTO0165 | PTO0497 | PTO0165 | PTO0497 | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase. | Archaeal kinase; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. | 0.879 |
| PTO0165 | PTO0572 | PTO0165 | PTO0572 | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase. | 4-hydroxybenzoate octaprenyltransferase. | 0.932 |
| PTO0165 | PTO0932 | PTO0165 | PTO0932 | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase. | 4-hydroxybenzoate octaprenyltransferase. | 0.972 |
| PTO0165 | ubiX | PTO0165 | PTO0191 | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase. | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.995 |
| PTO0190 | PTO0192 | PTO0190 | PTO0192 | Conserved hypothetical protein. | Mov34/MPN/PAD-1 family. | 0.773 |
| PTO0190 | pelA | PTO0190 | PTO0189 | Conserved hypothetical protein. | Predicted RNA-binding protein; May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity. | 0.878 |
| PTO0190 | ubiX | PTO0190 | PTO0191 | Conserved hypothetical protein. | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.835 |
| PTO0192 | PTO0190 | PTO0192 | PTO0190 | Mov34/MPN/PAD-1 family. | Conserved hypothetical protein. | 0.773 |
| PTO0192 | pelA | PTO0192 | PTO0189 | Mov34/MPN/PAD-1 family. | Predicted RNA-binding protein; May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity. | 0.830 |
| PTO0192 | ubiX | PTO0192 | PTO0191 | Mov34/MPN/PAD-1 family. | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.773 |
| PTO0374 | pelA | PTO0374 | PTO0189 | O-sialoglycoprotein endopeptidase/protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the protein kinase superfamily. Tyr prot [...] | Predicted RNA-binding protein; May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity. | 0.840 |
| PTO0374 | ubiX | PTO0374 | PTO0191 | O-sialoglycoprotein endopeptidase/protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the protein kinase superfamily. Tyr prot [...] | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.967 |
| PTO0478 | PTO0165 | PTO0478 | PTO0165 | Diphosphomevalonate decarboxylase; Catalyzes the ATP-independent decarboxylation of (R)- mevalonate 3,5-bisphosphate to isopentenyl phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3- phosphate rather than mevalonate 5-phosphate. Shows no detectable decarboxylase activity on mevalonate, mevalonate 3-phosphate, mevalonate 5-phosphate or mevalonate 5-pyrophosphate. | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase. | 0.766 |
| PTO0478 | PTO0497 | PTO0478 | PTO0497 | Diphosphomevalonate decarboxylase; Catalyzes the ATP-independent decarboxylation of (R)- mevalonate 3,5-bisphosphate to isopentenyl phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3- phosphate rather than mevalonate 5-phosphate. Shows no detectable decarboxylase activity on mevalonate, mevalonate 3-phosphate, mevalonate 5-phosphate or mevalonate 5-pyrophosphate. | Archaeal kinase; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. | 0.965 |
| PTO0478 | ubiX | PTO0478 | PTO0191 | Diphosphomevalonate decarboxylase; Catalyzes the ATP-independent decarboxylation of (R)- mevalonate 3,5-bisphosphate to isopentenyl phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3- phosphate rather than mevalonate 5-phosphate. Shows no detectable decarboxylase activity on mevalonate, mevalonate 3-phosphate, mevalonate 5-phosphate or mevalonate 5-pyrophosphate. | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.896 |
| PTO0497 | PTO0165 | PTO0497 | PTO0165 | Archaeal kinase; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase. | 0.879 |
| PTO0497 | PTO0478 | PTO0497 | PTO0478 | Archaeal kinase; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. | Diphosphomevalonate decarboxylase; Catalyzes the ATP-independent decarboxylation of (R)- mevalonate 3,5-bisphosphate to isopentenyl phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3- phosphate rather than mevalonate 5-phosphate. Shows no detectable decarboxylase activity on mevalonate, mevalonate 3-phosphate, mevalonate 5-phosphate or mevalonate 5-pyrophosphate. | 0.965 |
| PTO0497 | ubiX | PTO0497 | PTO0191 | Archaeal kinase; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.896 |
| PTO0572 | PTO0165 | PTO0572 | PTO0165 | 4-hydroxybenzoate octaprenyltransferase. | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase. | 0.932 |