| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PTO0209 | PTO0210 | PTO0209 | PTO0210 | Membrane associated serine protease. | Orotidine 5'-phosphate decarboxylase. | 0.631 |
| PTO0209 | PTO0211 | PTO0209 | PTO0211 | Membrane associated serine protease. | Putative signal peptide peptidase SppA. | 0.569 |
| PTO0209 | PTO0212 | PTO0209 | PTO0212 | Membrane associated serine protease. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Belongs to the UPF0284 family. | 0.569 |
| PTO0209 | pyrE | PTO0209 | PTO0208 | Membrane associated serine protease. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.552 |
| PTO0210 | PTO0209 | PTO0210 | PTO0209 | Orotidine 5'-phosphate decarboxylase. | Membrane associated serine protease. | 0.631 |
| PTO0210 | PTO0211 | PTO0210 | PTO0211 | Orotidine 5'-phosphate decarboxylase. | Putative signal peptide peptidase SppA. | 0.770 |
| PTO0210 | PTO0212 | PTO0210 | PTO0212 | Orotidine 5'-phosphate decarboxylase. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Belongs to the UPF0284 family. | 0.814 |
| PTO0210 | PTO0906 | PTO0210 | PTO0906 | Orotidine 5'-phosphate decarboxylase. | Ribose-phosphate pyrophosphokinase; Belongs to the ribose-phosphate pyrophosphokinase family. | 0.586 |
| PTO0210 | pyrE | PTO0210 | PTO0208 | Orotidine 5'-phosphate decarboxylase. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.999 |
| PTO0210 | thiI | PTO0210 | PTO0483 | Orotidine 5'-phosphate decarboxylase. | Hypothetical thiamine biosynthesis protein thiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.461 |
| PTO0211 | PTO0209 | PTO0211 | PTO0209 | Putative signal peptide peptidase SppA. | Membrane associated serine protease. | 0.569 |
| PTO0211 | PTO0210 | PTO0211 | PTO0210 | Putative signal peptide peptidase SppA. | Orotidine 5'-phosphate decarboxylase. | 0.770 |
| PTO0211 | PTO0212 | PTO0211 | PTO0212 | Putative signal peptide peptidase SppA. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Belongs to the UPF0284 family. | 0.777 |
| PTO0211 | PTO0700 | PTO0211 | PTO0700 | Putative signal peptide peptidase SppA. | Hypothetical phosphoserine phosphatase. | 0.584 |
| PTO0211 | PTO0906 | PTO0211 | PTO0906 | Putative signal peptide peptidase SppA. | Ribose-phosphate pyrophosphokinase; Belongs to the ribose-phosphate pyrophosphokinase family. | 0.423 |
| PTO0211 | ftsY | PTO0211 | PTO1516 | Putative signal peptide peptidase SppA. | Signal recognition particle receptor FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). | 0.498 |
| PTO0211 | metG | PTO0211 | PTO0542 | Putative signal peptide peptidase SppA. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.456 |
| PTO0211 | pyrE | PTO0211 | PTO0208 | Putative signal peptide peptidase SppA. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.443 |
| PTO0211 | thiI | PTO0211 | PTO0483 | Putative signal peptide peptidase SppA. | Hypothetical thiamine biosynthesis protein thiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.580 |
| PTO0212 | PTO0209 | PTO0212 | PTO0209 | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Belongs to the UPF0284 family. | Membrane associated serine protease. | 0.569 |