| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PTO0174 | PTO1311 | PTO0174 | PTO1311 | Dihydroorotate dehydrogenase electron transfer subunit. | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.697 |
| PTO0174 | hemA | PTO0174 | PTO0918 | Dihydroorotate dehydrogenase electron transfer subunit. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.671 |
| PTO0174 | hemC | PTO0174 | PTO0249 | Dihydroorotate dehydrogenase electron transfer subunit. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.712 |
| PTO0174 | hemL | PTO0174 | PTO0248 | Dihydroorotate dehydrogenase electron transfer subunit. | Glutamate-1-semialdehyde 2,1-aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. | 0.687 |
| PTO0174 | pyrD | PTO0174 | PTO0175 | Dihydroorotate dehydrogenase electron transfer subunit. | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. | 0.999 |
| PTO0246 | PTO0250 | PTO0246 | PTO0250 | Amidohydrolase; Belongs to the peptidase M20A family. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.678 |
| PTO0246 | hemC | PTO0246 | PTO0249 | Amidohydrolase; Belongs to the peptidase M20A family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.678 |
| PTO0246 | hemL | PTO0246 | PTO0248 | Amidohydrolase; Belongs to the peptidase M20A family. | Glutamate-1-semialdehyde 2,1-aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. | 0.683 |
| PTO0250 | PTO0246 | PTO0250 | PTO0246 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Amidohydrolase; Belongs to the peptidase M20A family. | 0.678 |
| PTO0250 | PTO1311 | PTO0250 | PTO1311 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.978 |
| PTO0250 | PTO1434 | PTO0250 | PTO1434 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Decarboxylating precorrin-6Y C5,15-methyltransferase. | 0.994 |
| PTO0250 | PTO1435 | PTO0250 | PTO1435 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.935 |
| PTO0250 | hemA | PTO0250 | PTO0918 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.807 |
| PTO0250 | hemC | PTO0250 | PTO0249 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.999 |
| PTO0250 | hemL | PTO0250 | PTO0248 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Glutamate-1-semialdehyde 2,1-aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. | 0.962 |
| PTO1311 | PTO0174 | PTO1311 | PTO0174 | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Dihydroorotate dehydrogenase electron transfer subunit. | 0.697 |
| PTO1311 | PTO0250 | PTO1311 | PTO0250 | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.978 |
| PTO1311 | PTO1434 | PTO1311 | PTO1434 | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Decarboxylating precorrin-6Y C5,15-methyltransferase. | 0.991 |
| PTO1311 | PTO1435 | PTO1311 | PTO1435 | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.943 |
| PTO1311 | hemA | PTO1311 | PTO0918 | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.954 |