| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PTO0347 | PTO0430 | PTO0347 | PTO0430 | Hypothetical protein DUF 74; Belongs to the UPF0145 family. | Diphthamide synthase subunit DPH2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.679 |
| PTO0430 | PTO0347 | PTO0430 | PTO0347 | Diphthamide synthase subunit DPH2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Hypothetical protein DUF 74; Belongs to the UPF0145 family. | 0.679 |
| PTO0430 | PTO0718 | PTO0430 | PTO0718 | Diphthamide synthase subunit DPH2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Ribosomal protein L11 methyltransferase. | 0.741 |
| PTO0430 | PTO0967 | PTO0430 | PTO0967 | Diphthamide synthase subunit DPH2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Putative ATPase; PP-loop superfamily. | 0.723 |
| PTO0430 | PTO1233 | PTO0430 | PTO1233 | Diphthamide synthase subunit DPH2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Diphthine synthase. | 0.934 |
| PTO0430 | PTO1519 | PTO0430 | PTO1519 | Diphthamide synthase subunit DPH2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. | 0.670 |
| PTO0430 | csl4 | PTO0430 | PTO0723 | Diphthamide synthase subunit DPH2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Putative RNA-binding protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. | 0.764 |
| PTO0430 | fusA | PTO0430 | PTO0417 | Diphthamide synthase subunit DPH2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Protein translation elongation factor; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/ [...] | 0.984 |
| PTO0430 | pcn | PTO0430 | PTO1316 | Diphthamide synthase subunit DPH2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.649 |
| PTO0430 | rpl10e | PTO0430 | PTO0715 | Diphthamide synthase subunit DPH2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 50S ribosomal protein L10e; Belongs to the universal ribosomal protein uL16 family. | 0.784 |
| PTO0430 | rpoL | PTO0430 | PTO0413 | Diphthamide synthase subunit DPH2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | DNA-directed RNA polymerase subunit L; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family. | 0.623 |
| PTO0718 | PTO0430 | PTO0718 | PTO0430 | Ribosomal protein L11 methyltransferase. | Diphthamide synthase subunit DPH2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.741 |
| PTO0718 | csl4 | PTO0718 | PTO0723 | Ribosomal protein L11 methyltransferase. | Putative RNA-binding protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. | 0.684 |
| PTO0718 | rpl10e | PTO0718 | PTO0715 | Ribosomal protein L11 methyltransferase. | 50S ribosomal protein L10e; Belongs to the universal ribosomal protein uL16 family. | 0.557 |
| PTO0718 | rpoL | PTO0718 | PTO0413 | Ribosomal protein L11 methyltransferase. | DNA-directed RNA polymerase subunit L; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family. | 0.591 |
| PTO0967 | PTO0430 | PTO0967 | PTO0430 | Putative ATPase; PP-loop superfamily. | Diphthamide synthase subunit DPH2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.723 |
| PTO0967 | PTO1233 | PTO0967 | PTO1233 | Putative ATPase; PP-loop superfamily. | Diphthine synthase. | 0.913 |
| PTO0967 | fusA | PTO0967 | PTO0417 | Putative ATPase; PP-loop superfamily. | Protein translation elongation factor; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/ [...] | 0.921 |
| PTO1233 | PTO0430 | PTO1233 | PTO0430 | Diphthine synthase. | Diphthamide synthase subunit DPH2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.934 |
| PTO1233 | PTO0967 | PTO1233 | PTO0967 | Diphthine synthase. | Putative ATPase; PP-loop superfamily. | 0.913 |
