| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PTO0165 | PTO0478 | PTO0165 | PTO0478 | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase. | Diphosphomevalonate decarboxylase; Catalyzes the ATP-independent decarboxylation of (R)- mevalonate 3,5-bisphosphate to isopentenyl phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3- phosphate rather than mevalonate 5-phosphate. Shows no detectable decarboxylase activity on mevalonate, mevalonate 3-phosphate, mevalonate 5-phosphate or mevalonate 5-pyrophosphate. | 0.766 |
| PTO0165 | PTO0497 | PTO0165 | PTO0497 | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase. | Archaeal kinase; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. | 0.879 |
| PTO0165 | ubiX | PTO0165 | PTO0191 | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase. | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.995 |
| PTO0384 | PTO0478 | PTO0384 | PTO0478 | 3-hydroxy-3-methylglutaryl-CoA-synthase/3- oxoacyl-[acyl-carrier-protein] synthase III; Belongs to the thiolase-like superfamily. UPF0219 family. | Diphosphomevalonate decarboxylase; Catalyzes the ATP-independent decarboxylation of (R)- mevalonate 3,5-bisphosphate to isopentenyl phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3- phosphate rather than mevalonate 5-phosphate. Shows no detectable decarboxylase activity on mevalonate, mevalonate 3-phosphate, mevalonate 5-phosphate or mevalonate 5-pyrophosphate. | 0.717 |
| PTO0384 | PTO0497 | PTO0384 | PTO0497 | 3-hydroxy-3-methylglutaryl-CoA-synthase/3- oxoacyl-[acyl-carrier-protein] synthase III; Belongs to the thiolase-like superfamily. UPF0219 family. | Archaeal kinase; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. | 0.599 |
| PTO0384 | PTO1143 | PTO0384 | PTO1143 | 3-hydroxy-3-methylglutaryl-CoA-synthase/3- oxoacyl-[acyl-carrier-protein] synthase III; Belongs to the thiolase-like superfamily. UPF0219 family. | 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | 0.997 |
| PTO0384 | PTO1199 | PTO0384 | PTO1199 | 3-hydroxy-3-methylglutaryl-CoA-synthase/3- oxoacyl-[acyl-carrier-protein] synthase III; Belongs to the thiolase-like superfamily. UPF0219 family. | Octaprenyl-diphosphate synthase; Farnesyl pyrophosphate synthetase/ geranyltransferase/farnesyltransferase/hexaprenyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 0.501 |
| PTO0478 | PTO0165 | PTO0478 | PTO0165 | Diphosphomevalonate decarboxylase; Catalyzes the ATP-independent decarboxylation of (R)- mevalonate 3,5-bisphosphate to isopentenyl phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3- phosphate rather than mevalonate 5-phosphate. Shows no detectable decarboxylase activity on mevalonate, mevalonate 3-phosphate, mevalonate 5-phosphate or mevalonate 5-pyrophosphate. | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase. | 0.766 |
| PTO0478 | PTO0384 | PTO0478 | PTO0384 | Diphosphomevalonate decarboxylase; Catalyzes the ATP-independent decarboxylation of (R)- mevalonate 3,5-bisphosphate to isopentenyl phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3- phosphate rather than mevalonate 5-phosphate. Shows no detectable decarboxylase activity on mevalonate, mevalonate 3-phosphate, mevalonate 5-phosphate or mevalonate 5-pyrophosphate. | 3-hydroxy-3-methylglutaryl-CoA-synthase/3- oxoacyl-[acyl-carrier-protein] synthase III; Belongs to the thiolase-like superfamily. UPF0219 family. | 0.717 |
| PTO0478 | PTO0479 | PTO0478 | PTO0479 | Diphosphomevalonate decarboxylase; Catalyzes the ATP-independent decarboxylation of (R)- mevalonate 3,5-bisphosphate to isopentenyl phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3- phosphate rather than mevalonate 5-phosphate. Shows no detectable decarboxylase activity on mevalonate, mevalonate 3-phosphate, mevalonate 5-phosphate or mevalonate 5-pyrophosphate. | Hypothetical phosphoglycerate kinase. | 0.983 |
| PTO0478 | PTO0497 | PTO0478 | PTO0497 | Diphosphomevalonate decarboxylase; Catalyzes the ATP-independent decarboxylation of (R)- mevalonate 3,5-bisphosphate to isopentenyl phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3- phosphate rather than mevalonate 5-phosphate. Shows no detectable decarboxylase activity on mevalonate, mevalonate 3-phosphate, mevalonate 5-phosphate or mevalonate 5-pyrophosphate. | Archaeal kinase; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. | 0.965 |
| PTO0478 | PTO0576 | PTO0478 | PTO0576 | Diphosphomevalonate decarboxylase; Catalyzes the ATP-independent decarboxylation of (R)- mevalonate 3,5-bisphosphate to isopentenyl phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3- phosphate rather than mevalonate 5-phosphate. Shows no detectable decarboxylase activity on mevalonate, mevalonate 3-phosphate, mevalonate 5-phosphate or mevalonate 5-pyrophosphate. | Transcriptional regulator. | 0.590 |
| PTO0478 | PTO0685 | PTO0478 | PTO0685 | Diphosphomevalonate decarboxylase; Catalyzes the ATP-independent decarboxylation of (R)- mevalonate 3,5-bisphosphate to isopentenyl phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3- phosphate rather than mevalonate 5-phosphate. Shows no detectable decarboxylase activity on mevalonate, mevalonate 3-phosphate, mevalonate 5-phosphate or mevalonate 5-pyrophosphate. | Oligopeptide ABC transporter Opp1, extracellular binding protein. | 0.601 |
| PTO0478 | PTO1143 | PTO0478 | PTO1143 | Diphosphomevalonate decarboxylase; Catalyzes the ATP-independent decarboxylation of (R)- mevalonate 3,5-bisphosphate to isopentenyl phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3- phosphate rather than mevalonate 5-phosphate. Shows no detectable decarboxylase activity on mevalonate, mevalonate 3-phosphate, mevalonate 5-phosphate or mevalonate 5-pyrophosphate. | 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | 0.740 |
| PTO0478 | PTO1199 | PTO0478 | PTO1199 | Diphosphomevalonate decarboxylase; Catalyzes the ATP-independent decarboxylation of (R)- mevalonate 3,5-bisphosphate to isopentenyl phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3- phosphate rather than mevalonate 5-phosphate. Shows no detectable decarboxylase activity on mevalonate, mevalonate 3-phosphate, mevalonate 5-phosphate or mevalonate 5-pyrophosphate. | Octaprenyl-diphosphate synthase; Farnesyl pyrophosphate synthetase/ geranyltransferase/farnesyltransferase/hexaprenyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 0.640 |
| PTO0478 | PTO1454 | PTO0478 | PTO1454 | Diphosphomevalonate decarboxylase; Catalyzes the ATP-independent decarboxylation of (R)- mevalonate 3,5-bisphosphate to isopentenyl phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3- phosphate rather than mevalonate 5-phosphate. Shows no detectable decarboxylase activity on mevalonate, mevalonate 3-phosphate, mevalonate 5-phosphate or mevalonate 5-pyrophosphate. | Transcriptional regulator. | 0.596 |
| PTO0478 | ubiX | PTO0478 | PTO0191 | Diphosphomevalonate decarboxylase; Catalyzes the ATP-independent decarboxylation of (R)- mevalonate 3,5-bisphosphate to isopentenyl phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3- phosphate rather than mevalonate 5-phosphate. Shows no detectable decarboxylase activity on mevalonate, mevalonate 3-phosphate, mevalonate 5-phosphate or mevalonate 5-pyrophosphate. | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.896 |
| PTO0479 | PTO0478 | PTO0479 | PTO0478 | Hypothetical phosphoglycerate kinase. | Diphosphomevalonate decarboxylase; Catalyzes the ATP-independent decarboxylation of (R)- mevalonate 3,5-bisphosphate to isopentenyl phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3- phosphate rather than mevalonate 5-phosphate. Shows no detectable decarboxylase activity on mevalonate, mevalonate 3-phosphate, mevalonate 5-phosphate or mevalonate 5-pyrophosphate. | 0.983 |
| PTO0497 | PTO0165 | PTO0497 | PTO0165 | Archaeal kinase; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase. | 0.879 |
| PTO0497 | PTO0384 | PTO0497 | PTO0384 | Archaeal kinase; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. | 3-hydroxy-3-methylglutaryl-CoA-synthase/3- oxoacyl-[acyl-carrier-protein] synthase III; Belongs to the thiolase-like superfamily. UPF0219 family. | 0.599 |
