| node1 | node2 | node1 annotation | node2 annotation | score |
| PTO0018 | PTO0478 | Extracellular solute-binding protein. | Diphosphomevalonate decarboxylase; Catalyzes the ATP-independent decarboxylation of (R)- mevalonate 3,5-bisphosphate to isopentenyl phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3- phosphate rather than mevalonate 5-phosphate. Shows no detectable decarboxylase activity on mevalonate, mevalonate 3-phosphate, mevalonate 5-phosphate or mevalonate 5-pyrophosphate. | 0.573 |
| PTO0018 | PTO0576 | Extracellular solute-binding protein. | Transcriptional regulator. | 0.695 |
| PTO0018 | PTO0577 | Extracellular solute-binding protein. | Hypothetical protein. | 0.705 |
| PTO0018 | PTO0578 | Extracellular solute-binding protein. | Putative maltose phosphorylase. | 0.694 |
| PTO0018 | PTO0796 | Extracellular solute-binding protein. | Hypothetical efflux protein. | 0.643 |
| PTO0018 | PTO1050 | Extracellular solute-binding protein. | Subtilase family protein. | 0.681 |
| PTO0018 | PTO1350 | Extracellular solute-binding protein. | Transporter. | 0.640 |
| PTO0180 | PTO0478 | Extracellular solute-binding protein. | Diphosphomevalonate decarboxylase; Catalyzes the ATP-independent decarboxylation of (R)- mevalonate 3,5-bisphosphate to isopentenyl phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3- phosphate rather than mevalonate 5-phosphate. Shows no detectable decarboxylase activity on mevalonate, mevalonate 3-phosphate, mevalonate 5-phosphate or mevalonate 5-pyrophosphate. | 0.544 |
| PTO0180 | PTO0576 | Extracellular solute-binding protein. | Transcriptional regulator. | 0.676 |
| PTO0180 | PTO0577 | Extracellular solute-binding protein. | Hypothetical protein. | 0.697 |
| PTO0180 | PTO0578 | Extracellular solute-binding protein. | Putative maltose phosphorylase. | 0.664 |
| PTO0180 | PTO0796 | Extracellular solute-binding protein. | Hypothetical efflux protein. | 0.605 |
| PTO0180 | PTO1050 | Extracellular solute-binding protein. | Subtilase family protein. | 0.646 |
| PTO0180 | PTO1350 | Extracellular solute-binding protein. | Transporter. | 0.635 |
| PTO0478 | PTO0018 | Diphosphomevalonate decarboxylase; Catalyzes the ATP-independent decarboxylation of (R)- mevalonate 3,5-bisphosphate to isopentenyl phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3- phosphate rather than mevalonate 5-phosphate. Shows no detectable decarboxylase activity on mevalonate, mevalonate 3-phosphate, mevalonate 5-phosphate or mevalonate 5-pyrophosphate. | Extracellular solute-binding protein. | 0.573 |
| PTO0478 | PTO0180 | Diphosphomevalonate decarboxylase; Catalyzes the ATP-independent decarboxylation of (R)- mevalonate 3,5-bisphosphate to isopentenyl phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3- phosphate rather than mevalonate 5-phosphate. Shows no detectable decarboxylase activity on mevalonate, mevalonate 3-phosphate, mevalonate 5-phosphate or mevalonate 5-pyrophosphate. | Extracellular solute-binding protein. | 0.544 |
| PTO0478 | PTO0576 | Diphosphomevalonate decarboxylase; Catalyzes the ATP-independent decarboxylation of (R)- mevalonate 3,5-bisphosphate to isopentenyl phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3- phosphate rather than mevalonate 5-phosphate. Shows no detectable decarboxylase activity on mevalonate, mevalonate 3-phosphate, mevalonate 5-phosphate or mevalonate 5-pyrophosphate. | Transcriptional regulator. | 0.590 |
| PTO0478 | PTO0577 | Diphosphomevalonate decarboxylase; Catalyzes the ATP-independent decarboxylation of (R)- mevalonate 3,5-bisphosphate to isopentenyl phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3- phosphate rather than mevalonate 5-phosphate. Shows no detectable decarboxylase activity on mevalonate, mevalonate 3-phosphate, mevalonate 5-phosphate or mevalonate 5-pyrophosphate. | Hypothetical protein. | 0.583 |
| PTO0478 | PTO0578 | Diphosphomevalonate decarboxylase; Catalyzes the ATP-independent decarboxylation of (R)- mevalonate 3,5-bisphosphate to isopentenyl phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3- phosphate rather than mevalonate 5-phosphate. Shows no detectable decarboxylase activity on mevalonate, mevalonate 3-phosphate, mevalonate 5-phosphate or mevalonate 5-pyrophosphate. | Putative maltose phosphorylase. | 0.554 |
| PTO0478 | PTO0685 | Diphosphomevalonate decarboxylase; Catalyzes the ATP-independent decarboxylation of (R)- mevalonate 3,5-bisphosphate to isopentenyl phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3- phosphate rather than mevalonate 5-phosphate. Shows no detectable decarboxylase activity on mevalonate, mevalonate 3-phosphate, mevalonate 5-phosphate or mevalonate 5-pyrophosphate. | Oligopeptide ABC transporter Opp1, extracellular binding protein. | 0.601 |
