| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PTO0128 | PTO0673 | PTO0128 | PTO0673 | DNA polymerase delta catalytic subunit. | Replication factor A, large subunit. | 0.872 |
| PTO0128 | PTO1217 | PTO0128 | PTO1217 | DNA polymerase delta catalytic subunit. | Cell division control protein (mcm family); Belongs to the MCM family. | 0.972 |
| PTO0128 | PTO1418 | PTO0128 | PTO1418 | DNA polymerase delta catalytic subunit. | Hypothetical protein. | 0.441 |
| PTO0128 | cdc6 | PTO0128 | PTO1257 | DNA polymerase delta catalytic subunit. | Origin recognition complex subunit; Involved in regulation of DNA replication. | 0.881 |
| PTO0128 | fen | PTO0128 | PTO0228 | DNA polymerase delta catalytic subunit. | RAD-2/FEN-1 exonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathwa [...] | 0.959 |
| PTO0128 | mre11 | PTO0128 | PTO0240 | DNA polymerase delta catalytic subunit. | DNA repair protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.704 |
| PTO0128 | pcn | PTO0128 | PTO1316 | DNA polymerase delta catalytic subunit. | DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.995 |
| PTO0128 | priL | PTO0128 | PTO0982 | DNA polymerase delta catalytic subunit. | DNA primase 58 kDa subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.992 |
| PTO0128 | priS | PTO0128 | PTO0802 | DNA polymerase delta catalytic subunit. | DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] | 0.990 |
| PTO0128 | radA | PTO0128 | PTO0741 | DNA polymerase delta catalytic subunit. | DNA repair and recombination protein radA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.878 |
| PTO0673 | PTO0128 | PTO0673 | PTO0128 | Replication factor A, large subunit. | DNA polymerase delta catalytic subunit. | 0.872 |
| PTO0673 | PTO1217 | PTO0673 | PTO1217 | Replication factor A, large subunit. | Cell division control protein (mcm family); Belongs to the MCM family. | 0.879 |
| PTO0673 | PTO1418 | PTO0673 | PTO1418 | Replication factor A, large subunit. | Hypothetical protein. | 0.794 |
| PTO0673 | cdc6 | PTO0673 | PTO1257 | Replication factor A, large subunit. | Origin recognition complex subunit; Involved in regulation of DNA replication. | 0.768 |
| PTO0673 | fen | PTO0673 | PTO0228 | Replication factor A, large subunit. | RAD-2/FEN-1 exonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathwa [...] | 0.812 |
| PTO0673 | mre11 | PTO0673 | PTO0240 | Replication factor A, large subunit. | DNA repair protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.833 |
| PTO0673 | pcn | PTO0673 | PTO1316 | Replication factor A, large subunit. | DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.932 |
| PTO0673 | priL | PTO0673 | PTO0982 | Replication factor A, large subunit. | DNA primase 58 kDa subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.877 |
| PTO0673 | priS | PTO0673 | PTO0802 | Replication factor A, large subunit. | DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] | 0.766 |
| PTO0673 | radA | PTO0673 | PTO0741 | Replication factor A, large subunit. | DNA repair and recombination protein radA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.839 |