| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PTO0710 | PTO0711 | PTO0710 | PTO0711 | Hypothetical protein; Involved in riboflavin synthesis. | N-ethylammeline chlorohydrolase. | 0.856 |
| PTO0710 | PTO0712 | PTO0710 | PTO0712 | Hypothetical protein; Involved in riboflavin synthesis. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | 0.975 |
| PTO0710 | PTO0713 | PTO0710 | PTO0713 | Hypothetical protein; Involved in riboflavin synthesis. | Riboflavin synthase. | 0.471 |
| PTO0710 | ribH | PTO0710 | PTO0714 | Hypothetical protein; Involved in riboflavin synthesis. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.962 |
| PTO0711 | PTO0710 | PTO0711 | PTO0710 | N-ethylammeline chlorohydrolase. | Hypothetical protein; Involved in riboflavin synthesis. | 0.856 |
| PTO0711 | PTO0712 | PTO0711 | PTO0712 | N-ethylammeline chlorohydrolase. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | 0.897 |
| PTO0711 | PTO0713 | PTO0711 | PTO0713 | N-ethylammeline chlorohydrolase. | Riboflavin synthase. | 0.935 |
| PTO0711 | ribH | PTO0711 | PTO0714 | N-ethylammeline chlorohydrolase. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.875 |
| PTO0712 | PTO0710 | PTO0712 | PTO0710 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | Hypothetical protein; Involved in riboflavin synthesis. | 0.975 |
| PTO0712 | PTO0711 | PTO0712 | PTO0711 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | N-ethylammeline chlorohydrolase. | 0.897 |
| PTO0712 | PTO0713 | PTO0712 | PTO0713 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | Riboflavin synthase. | 0.977 |
| PTO0712 | ribH | PTO0712 | PTO0714 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.999 |
| PTO0712 | ribK | PTO0712 | PTO0969 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | Hypothetical conserved archaeal protein; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. | 0.684 |
| PTO0712 | ribL | PTO0712 | PTO1010 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | Glycerol-3-phosphate cytidylyltransferase; Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme. | 0.704 |
| PTO0713 | PTO0710 | PTO0713 | PTO0710 | Riboflavin synthase. | Hypothetical protein; Involved in riboflavin synthesis. | 0.471 |
| PTO0713 | PTO0711 | PTO0713 | PTO0711 | Riboflavin synthase. | N-ethylammeline chlorohydrolase. | 0.935 |
| PTO0713 | PTO0712 | PTO0713 | PTO0712 | Riboflavin synthase. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | 0.977 |
| PTO0713 | PTO1064 | PTO0713 | PTO1064 | Riboflavin synthase. | 6-pyruvoyltetrahydrobiopterin synthase. | 0.507 |
| PTO0713 | PTO1105 | PTO0713 | PTO1105 | Riboflavin synthase. | Transcriptional regulatory protein. | 0.563 |
| PTO0713 | pfdB | PTO0713 | PTO1008 | Riboflavin synthase. | Hypothetical prefoldin beta subunit; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. | 0.616 |