| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PTO0185 | PTO0186 | PTO0185 | PTO0186 | Methionine synthase II, cobalamin-independent. | Methionine synthase II, cobalamin-independent. | 0.986 |
| PTO0185 | PTO0477 | PTO0185 | PTO0477 | Methionine synthase II, cobalamin-independent. | Cystathionine beta-lyase. | 0.940 |
| PTO0185 | PTO0980 | PTO0185 | PTO0980 | Methionine synthase II, cobalamin-independent. | Hypothetical phosphodiesterase. | 0.890 |
| PTO0185 | mat | PTO0185 | PTO0744 | Methionine synthase II, cobalamin-independent. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. | 0.892 |
| PTO0186 | PTO0185 | PTO0186 | PTO0185 | Methionine synthase II, cobalamin-independent. | Methionine synthase II, cobalamin-independent. | 0.986 |
| PTO0186 | PTO0477 | PTO0186 | PTO0477 | Methionine synthase II, cobalamin-independent. | Cystathionine beta-lyase. | 0.939 |
| PTO0186 | PTO0980 | PTO0186 | PTO0980 | Methionine synthase II, cobalamin-independent. | Hypothetical phosphodiesterase. | 0.890 |
| PTO0186 | PTO1335 | PTO0186 | PTO1335 | Methionine synthase II, cobalamin-independent. | Imidazole glycerol phosphate dehydratase. | 0.498 |
| PTO0186 | mat | PTO0186 | PTO0744 | Methionine synthase II, cobalamin-independent. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. | 0.916 |
| PTO0328 | mat | PTO0328 | PTO0744 | Peptidyl-prolyl cis-trans isomerase. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. | 0.771 |
| PTO0328 | thiI | PTO0328 | PTO0483 | Peptidyl-prolyl cis-trans isomerase. | Hypothetical thiamine biosynthesis protein thiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.711 |
| PTO0477 | PTO0185 | PTO0477 | PTO0185 | Cystathionine beta-lyase. | Methionine synthase II, cobalamin-independent. | 0.940 |
| PTO0477 | PTO0186 | PTO0477 | PTO0186 | Cystathionine beta-lyase. | Methionine synthase II, cobalamin-independent. | 0.939 |
| PTO0477 | mat | PTO0477 | PTO0744 | Cystathionine beta-lyase. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. | 0.639 |
| PTO0980 | PTO0185 | PTO0980 | PTO0185 | Hypothetical phosphodiesterase. | Methionine synthase II, cobalamin-independent. | 0.890 |
| PTO0980 | PTO0186 | PTO0980 | PTO0186 | Hypothetical phosphodiesterase. | Methionine synthase II, cobalamin-independent. | 0.890 |
| PTO0980 | mat | PTO0980 | PTO0744 | Hypothetical phosphodiesterase. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. | 0.890 |
| PTO0980 | thiI | PTO0980 | PTO0483 | Hypothetical phosphodiesterase. | Hypothetical thiamine biosynthesis protein thiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.764 |
| PTO1333 | PTO1335 | PTO1333 | PTO1335 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | Imidazole glycerol phosphate dehydratase. | 0.998 |
| PTO1333 | PTO1337 | PTO1333 | PTO1337 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | ATP phosphoribosyltransferase. | 0.997 |