node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PTO0374 | PTO0866 | PTO0374 | PTO0866 | O-sialoglycoprotein endopeptidase/protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the protein kinase superfamily. Tyr prot [...] | DNA-directed RNA polymerase subunit E'. | 0.999 |
PTO0374 | PTO0868 | PTO0374 | PTO0868 | O-sialoglycoprotein endopeptidase/protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the protein kinase superfamily. Tyr prot [...] | Archaeal conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | 0.999 |
PTO0374 | rps24e | PTO0374 | PTO0869 | O-sialoglycoprotein endopeptidase/protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the protein kinase superfamily. Tyr prot [...] | Small subunit ribosomal protein S24E; Belongs to the eukaryotic ribosomal protein eS24 family. | 0.999 |
PTO0374 | rps27ae | PTO0374 | PTO0870 | O-sialoglycoprotein endopeptidase/protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the protein kinase superfamily. Tyr prot [...] | Small subunit ribosomal protein S27AE; Belongs to the eukaryotic ribosomal protein eS31 family. | 0.999 |
PTO0374 | rps6e | PTO0374 | PTO0591 | O-sialoglycoprotein endopeptidase/protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the protein kinase superfamily. Tyr prot [...] | Small subunit ribosomal protein S6E; Belongs to the eukaryotic ribosomal protein eS6 family. | 0.989 |
PTO0374 | spt4 | PTO0374 | PTO0867 | O-sialoglycoprotein endopeptidase/protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the protein kinase superfamily. Tyr prot [...] | DNA-directed RNA polymerase subunit E; Stimulates transcription elongation; Belongs to the archaeal Spt4 family. | 0.999 |
PTO0508 | PTO0868 | PTO0508 | PTO0868 | Glycerol-3-phosphate cytidylyltransferase. | Archaeal conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | 0.930 |
PTO0835 | PTO0868 | PTO0835 | PTO0868 | Hypothetical archaea-specific FeS oxidoreductase. | Archaeal conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | 0.572 |
PTO0835 | mptE | PTO0835 | PTO0435 | Hypothetical archaea-specific FeS oxidoreductase. | Hypothetical protein DUF115; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP). | 0.443 |
PTO0835 | tiaS | PTO0835 | PTO1377 | Hypothetical archaea-specific FeS oxidoreductase. | Hypothetical protein; ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA. | 0.520 |
PTO0866 | PTO0374 | PTO0866 | PTO0374 | DNA-directed RNA polymerase subunit E'. | O-sialoglycoprotein endopeptidase/protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the protein kinase superfamily. Tyr prot [...] | 0.999 |
PTO0866 | PTO0868 | PTO0866 | PTO0868 | DNA-directed RNA polymerase subunit E'. | Archaeal conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | 0.986 |
PTO0866 | rps24e | PTO0866 | PTO0869 | DNA-directed RNA polymerase subunit E'. | Small subunit ribosomal protein S24E; Belongs to the eukaryotic ribosomal protein eS24 family. | 0.971 |
PTO0866 | rps27ae | PTO0866 | PTO0870 | DNA-directed RNA polymerase subunit E'. | Small subunit ribosomal protein S27AE; Belongs to the eukaryotic ribosomal protein eS31 family. | 0.954 |
PTO0866 | rps6e | PTO0866 | PTO0591 | DNA-directed RNA polymerase subunit E'. | Small subunit ribosomal protein S6E; Belongs to the eukaryotic ribosomal protein eS6 family. | 0.546 |
PTO0866 | spt4 | PTO0866 | PTO0867 | DNA-directed RNA polymerase subunit E'. | DNA-directed RNA polymerase subunit E; Stimulates transcription elongation; Belongs to the archaeal Spt4 family. | 0.998 |
PTO0868 | PTO0374 | PTO0868 | PTO0374 | Archaeal conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | O-sialoglycoprotein endopeptidase/protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the protein kinase superfamily. Tyr prot [...] | 0.999 |
PTO0868 | PTO0508 | PTO0868 | PTO0508 | Archaeal conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | Glycerol-3-phosphate cytidylyltransferase. | 0.930 |
PTO0868 | PTO0835 | PTO0868 | PTO0835 | Archaeal conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | Hypothetical archaea-specific FeS oxidoreductase. | 0.572 |
PTO0868 | PTO0866 | PTO0868 | PTO0866 | Archaeal conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | DNA-directed RNA polymerase subunit E'. | 0.986 |