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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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[Homology]
Score
fhsFormate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (535 aa)    
Predicted Functional Partners:
folD
Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
   
  0.994
PTO0745
Phosphoribosylaminoimidazolecarboxamide formyltransferase.
  
 0.982
PTO1242
Glutamate formiminotransferase; Catalyzes the transfer of the formyl group from N- formylglutamate to tetrahydrofolate (THF) to yield 5- formyltetrahydrofolate (5-CHO-THF) and glutamate (Glu). The triglutamate form of 5-CHO-THF (5-CHO-THF-Glu3) can also be used as substrate. It can also catalyzes the transfer of the formimino group from N-formiminoglutamate to tetrahydrofolate (THF) to yield 5- formiminotetrahydrofolate (5-NH=CH-THF) and glutamate (Glu). It can replace YgfA to catalyzes the irreversible ATP-dependent transformation of 5-CHO-THF to form 5,10-methenyltetrahydrofolate (5, [...]
    
 0.972
PTO0379
Phosphoribosylglycinamide formyltransferase.
  
 0.965
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.957
PTO0858
Serine hydroxymethyltransferase.
  
 0.957
PTO0503
Aminomethyltransferase.
  
 0.940
PTO1243
Formiminotransferase-cyclodeaminase.
    
 0.917
purC
Phosphoribosylamidoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family.
  
 
 0.826
PTO0950
Phosphoribosylamine--glycine ligase.
  
 0.737
Your Current Organism:
Picrophilus torridus
NCBI taxonomy Id: 263820
Other names: P. torridus DSM 9790, Picrophilus torridus DSM 9790, Picrophilus torridus DSM9790, Picrophilus torridus str. DSM 9790, Picrophilus torridus strain DSM 9790
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