node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AAZ59844.1 | AAZ60327.1 | Reut_A0462 | Reut_A0948 | Tartrate dehydrogenase. | Acetolactate synthase, small subunit. | 0.979 |
AAZ59844.1 | AAZ61803.1 | Reut_A0462 | Reut_A2441 | Tartrate dehydrogenase. | Malate dehydrogenase (oxaloacetate decarboxylating) (NADP+)/phosphate acetyltransferase. | 0.464 |
AAZ59844.1 | AAZ62868.1 | Reut_A0462 | Reut_B3510 | Tartrate dehydrogenase. | Acetolactate synthase I/II/III large subunit; Thiamine pyrophosphate enzyme, C-terminal TPP-binding:Thiamine pyrophosphate enzyme, N-terminal TPP binding region. | 0.937 |
AAZ59844.1 | AAZ63469.1 | Reut_A0462 | Reut_B4115 | Tartrate dehydrogenase. | Tartrate dehydrogenase. | 0.901 |
AAZ59844.1 | ilvC | Reut_A0462 | Reut_A0949 | Tartrate dehydrogenase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.805 |
AAZ59844.1 | leuA | Reut_A0462 | Reut_A0953 | Tartrate dehydrogenase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.792 |
AAZ59844.1 | leuA-2 | Reut_A0462 | Reut_A1687 | Tartrate dehydrogenase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.647 |
AAZ60327.1 | AAZ59844.1 | Reut_A0948 | Reut_A0462 | Acetolactate synthase, small subunit. | Tartrate dehydrogenase. | 0.979 |
AAZ60327.1 | AAZ61803.1 | Reut_A0948 | Reut_A2441 | Acetolactate synthase, small subunit. | Malate dehydrogenase (oxaloacetate decarboxylating) (NADP+)/phosphate acetyltransferase. | 0.863 |
AAZ60327.1 | AAZ62868.1 | Reut_A0948 | Reut_B3510 | Acetolactate synthase, small subunit. | Acetolactate synthase I/II/III large subunit; Thiamine pyrophosphate enzyme, C-terminal TPP-binding:Thiamine pyrophosphate enzyme, N-terminal TPP binding region. | 0.903 |
AAZ60327.1 | AAZ63469.1 | Reut_A0948 | Reut_B4115 | Acetolactate synthase, small subunit. | Tartrate dehydrogenase. | 0.978 |
AAZ60327.1 | ilvA | Reut_A0948 | Reut_A0413 | Acetolactate synthase, small subunit. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.969 |
AAZ60327.1 | ilvA-2 | Reut_A0948 | Reut_B4909 | Acetolactate synthase, small subunit. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.969 |
AAZ60327.1 | ilvC | Reut_A0948 | Reut_A0949 | Acetolactate synthase, small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.998 |
AAZ60327.1 | leuA | Reut_A0948 | Reut_A0953 | Acetolactate synthase, small subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.966 |
AAZ60327.1 | leuA-2 | Reut_A0948 | Reut_A1687 | Acetolactate synthase, small subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.958 |
AAZ60327.1 | leuB | Reut_A0948 | Reut_A2311 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.989 |
AAZ61803.1 | AAZ59844.1 | Reut_A2441 | Reut_A0462 | Malate dehydrogenase (oxaloacetate decarboxylating) (NADP+)/phosphate acetyltransferase. | Tartrate dehydrogenase. | 0.464 |
AAZ61803.1 | AAZ60327.1 | Reut_A2441 | Reut_A0948 | Malate dehydrogenase (oxaloacetate decarboxylating) (NADP+)/phosphate acetyltransferase. | Acetolactate synthase, small subunit. | 0.863 |
AAZ61803.1 | AAZ62868.1 | Reut_A2441 | Reut_B3510 | Malate dehydrogenase (oxaloacetate decarboxylating) (NADP+)/phosphate acetyltransferase. | Acetolactate synthase I/II/III large subunit; Thiamine pyrophosphate enzyme, C-terminal TPP-binding:Thiamine pyrophosphate enzyme, N-terminal TPP binding region. | 0.873 |