STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
comXTranscriptional regulator, competence factor,RNA polymerase sigma factor; Belongs to the sigma-70 factor family. (165 aa)    
Predicted Functional Partners:
dprA
DNA processing protein, Smf family.
      
 0.782
eep
Conserved hypothetical, predicted membrane protein (TMS5).
      
 0.776
comEA
Late competence protein required for DNA binding and uptake.
   
  
 0.662
plcR
Transcriptional regulator.
      
 0.574
ssbB
Single strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
   
  
 0.512
mecA
Negative regulator of genetic competence, putative; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.
      
 0.489
xer1
Integrase/recombinase, tyrosine family; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.
      
 0.489
endA
Competence associated membrane nuclease.
      
 0.489
comEC
Late competence protein required for DNA uptake.
      
 0.442
Your Current Organism:
Streptococcus thermophilus
NCBI taxonomy Id: 264199
Other names: S. thermophilus LMG 18311, Streptococcus thermophilus LMG 18311, Streptococcus thermophilus str. LMG 18311, Streptococcus thermophilus strain LMG 18311
Server load: low (34%) [HD]