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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mecANegative regulator of genetic competence, putative; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. (249 aa)    
Predicted Functional Partners:
clpC
ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family.
    
 
 0.876
rgpG
Exopolysaccharide biosynthesis protein, glycosyltransferase.
     
 0.810
ezrA
Septation ring formation regulator; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family.
  
     0.768
coiA
Competence protein, transcription factor.
 
     0.751
stu1608
ABC transporter membrane-spanning protein.
  
     0.751
stu1858
Conserved hypothetical protein.
  
     0.726
clpE
ATP-dependent Clp protease; Belongs to the ClpA/ClpB family.
    
 
 0.720
stu1141
Conserved hypothetical protein, TPR domain protein.
  
     0.715
clpL
ATP-dependent proteinase ATP-binding subunit; Belongs to the ClpA/ClpB family.
    
 
 0.698
rpoE
DNA-directed RNA polymerase delta subunit; Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; Belongs to the RpoE family.
  
     0.691
Your Current Organism:
Streptococcus thermophilus
NCBI taxonomy Id: 264199
Other names: S. thermophilus LMG 18311, Streptococcus thermophilus LMG 18311, Streptococcus thermophilus str. LMG 18311, Streptococcus thermophilus strain LMG 18311
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