STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nifRPossible transcriptional regulator; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (350 aa)    
Predicted Functional Partners:
hslO
Heat shock protein, chaperonin, 33 kDa; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
  
  
 0.828
truA
tRNA pseudouridine synthase A (pseudouridylate synthase I); Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
 
 
 0.585
pheT
phenylalanyl-tRNA synthetase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
 
  
 0.550
stu0179
Unknown protein.
       0.515
polA
DNA-directed DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
 
    0.503
guaB
Inosine monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
  
 0.484
comEC
Late competence protein required for DNA uptake.
 
   
 0.477
stu1000
rRNA methyltransferase, putative.
  
 
 0.470
trmB
Conserved hypothetical protein, methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
  
 
 0.469
stu0182
Positive transcriptional regulator MutR family.
  
    0.461
Your Current Organism:
Streptococcus thermophilus
NCBI taxonomy Id: 264199
Other names: S. thermophilus LMG 18311, Streptococcus thermophilus LMG 18311, Streptococcus thermophilus str. LMG 18311, Streptococcus thermophilus strain LMG 18311
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.