Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
stu0248Conserved hypothetical protein, putative hydrolase. (164 aa)    
Predicted Functional Partners:
stu0249
Conserved hypothetical, predicted membrane protein (TMS7); Belongs to the BI1 family.
  
    0.803
spoU
rRNA methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
       0.716
acyP
Acylphosphatase.
     
 0.651
yidC
Cytochrome oxidase biogenesis (Oxa1) family protein, similar to SpoIIIJ; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins; Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
  
  
 0.606
lysA
Diaminopimelate decarboxylase.
 
     0.514
mprF
Conserved hypothetical, predicted membrane protein (TMS14); Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.
 
    0.502
stu1462
Conserved hypothetical protein.
  
     0.467
stu1136
Unknown protein.
 
 
   0.463
yajC
Preprotein translocase, YajC subunit, putative.
  
 
   0.429
cinA
Competence/damage inducible protein; Belongs to the CinA family.
 
    0.428
Your Current Organism:
Streptococcus thermophilus
NCBI taxonomy Id: 264199
Other names: S. thermophilus LMG 18311, Streptococcus thermophilus LMG 18311, Streptococcus thermophilus str. LMG 18311, Streptococcus thermophilus strain LMG 18311
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