| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| glr | scpA | stu0255 | stu0260 | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | Conserved hypothetical protein; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves. | 0.811 |
| glr | scpB | stu0255 | stu0261 | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | Conserved hypothetical protein; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. | 0.805 |
| glr | stu0256 | stu0255 | stu0256 | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.979 |
| glr | stu0257 | stu0255 | stu0257 | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | Conserved hypothetical protein. | 0.800 |
| guaA | guaB | stu0886 | stu2016 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Inosine monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
| guaA | hpt | stu0886 | stu0011 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Hypoxantine-guanine phosphorybosyltransferase. | 0.954 |
| guaA | ndk | stu0886 | stu0906 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.493 |
| guaA | stu0256 | stu0886 | stu0256 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.964 |
| guaA | stu0979 | stu0886 | stu0979 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 5'-nucleotidase, putative; Belongs to the 5'-nucleotidase family. | 0.907 |
| guaA | stu1338 | stu0886 | stu1338 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Xanthine phosphoribosyltransferase, truncated; Truncated. | 0.979 |
| guaB | guaA | stu2016 | stu0886 | Inosine monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.999 |
| guaB | hpt | stu2016 | stu0011 | Inosine monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Hypoxantine-guanine phosphorybosyltransferase. | 0.959 |
| guaB | ndk | stu2016 | stu0906 | Inosine monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.522 |
| guaB | stu0256 | stu2016 | stu0256 | Inosine monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.946 |
| guaB | stu0979 | stu2016 | stu0979 | Inosine monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 5'-nucleotidase, putative; Belongs to the 5'-nucleotidase family. | 0.915 |
| guaB | stu1338 | stu2016 | stu1338 | Inosine monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Xanthine phosphoribosyltransferase, truncated; Truncated. | 0.946 |
| hpt | guaA | stu0011 | stu0886 | Hypoxantine-guanine phosphorybosyltransferase. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.954 |
| hpt | guaB | stu0011 | stu2016 | Hypoxantine-guanine phosphorybosyltransferase. | Inosine monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.959 |
| hpt | stu0256 | stu0011 | stu0256 | Hypoxantine-guanine phosphorybosyltransferase. | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.909 |
| hpt | stu0979 | stu0011 | stu0979 | Hypoxantine-guanine phosphorybosyltransferase. | 5'-nucleotidase, putative; Belongs to the 5'-nucleotidase family. | 0.900 |