STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
plcRTranscriptional regulator. (299 aa)    
Predicted Functional Partners:
eep
Conserved hypothetical, predicted membrane protein (TMS5).
     
 0.803
lspA
Prolipoprotein signal peptidase (spase II); This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family.
      
 0.780
blpC
Signal peptide, putative.
      
 0.729
comX
Transcriptional regulator, competence factor,RNA polymerase sigma factor; Belongs to the sigma-70 factor family.
      
 0.574
htrA
Exported serine protease.
   
  
 0.484
stu0271
Peptide-2 ABC exporter (Pep2E) family, ATP binding/membrane-spanning protein, truncated; Truncated.
       0.458
ribU
Conserved hypothetical, predicted membrane protein (TMS5); Substrate-binding (S) component of an energy-coupling factor (ECF) ABC-transporter complex. Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins (Probable). Expression of the compl [...]
       0.441
stu0269
Conserved hypothetical, predicted membrane protein (TMS6).
  
    0.441
codY
Transcriptional pleiotropic repressor; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family.
      
 0.410
stu0272
Peptide-2 ABC exporter (Pep2E) family, ATP binding/membrane-spanning protein, truncated; Truncated.
       0.406
Your Current Organism:
Streptococcus thermophilus
NCBI taxonomy Id: 264199
Other names: S. thermophilus LMG 18311, Streptococcus thermophilus LMG 18311, Streptococcus thermophilus str. LMG 18311, Streptococcus thermophilus strain LMG 18311
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