| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cmhR | metE | stu0872 | stu0785 | Probable metCcysK operon transcriptional activator; Belongs to the LysR transcriptional regulatory family. | 5-methyl tetrahydropteroyltriglutamate -- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.653 |
| cmhR | metF | stu0872 | stu0786 | Probable metCcysK operon transcriptional activator; Belongs to the LysR transcriptional regulatory family. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.698 |
| cmhR | metK | stu0872 | stu1172 | Probable metCcysK operon transcriptional activator; Belongs to the LysR transcriptional regulatory family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.628 |
| cmhR | metN | stu0872 | stu0301 | Probable metCcysK operon transcriptional activator; Belongs to the LysR transcriptional regulatory family. | Polar amino acid ABC uptake transporter ATP binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.777 |
| metE | cmhR | stu0785 | stu0872 | 5-methyl tetrahydropteroyltriglutamate -- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | Probable metCcysK operon transcriptional activator; Belongs to the LysR transcriptional regulatory family. | 0.653 |
| metE | metF | stu0785 | stu0786 | 5-methyl tetrahydropteroyltriglutamate -- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.978 |
| metE | metK | stu0785 | stu1172 | 5-methyl tetrahydropteroyltriglutamate -- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.976 |
| metE | metN | stu0785 | stu0301 | 5-methyl tetrahydropteroyltriglutamate -- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | Polar amino acid ABC uptake transporter ATP binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.645 |
| metF | cmhR | stu0786 | stu0872 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Probable metCcysK operon transcriptional activator; Belongs to the LysR transcriptional regulatory family. | 0.698 |
| metF | metE | stu0786 | stu0785 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 5-methyl tetrahydropteroyltriglutamate -- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.978 |
| metF | metK | stu0786 | stu1172 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.833 |
| metF | metN | stu0786 | stu0301 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Polar amino acid ABC uptake transporter ATP binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.850 |
| metF | stu0302 | stu0786 | stu0302 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | ABC transporter membrane-spanning protein. | 0.501 |
| metK | cmhR | stu1172 | stu0872 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Probable metCcysK operon transcriptional activator; Belongs to the LysR transcriptional regulatory family. | 0.628 |
| metK | metE | stu1172 | stu0785 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 5-methyl tetrahydropteroyltriglutamate -- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.976 |
| metK | metF | stu1172 | stu0786 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.833 |
| metK | metN | stu1172 | stu0301 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Polar amino acid ABC uptake transporter ATP binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.840 |
| metN | cmhR | stu0301 | stu0872 | Polar amino acid ABC uptake transporter ATP binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | Probable metCcysK operon transcriptional activator; Belongs to the LysR transcriptional regulatory family. | 0.777 |
| metN | metE | stu0301 | stu0785 | Polar amino acid ABC uptake transporter ATP binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 5-methyl tetrahydropteroyltriglutamate -- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.645 |
| metN | metF | stu0301 | stu0786 | Polar amino acid ABC uptake transporter ATP binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.850 |