STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (286 aa)    
Predicted Functional Partners:
thrC
Threonine synthase.
 
 0.999
hom
Homoserine dehydrogenase.
 
 0.997
purM
Phosphoribosylformylglycinamide cyclo-ligase (AIR synthetase).
 
    
 0.908
bcaT
Branched chain amino acid aminotransferase.
  
 
 0.848
sdaB
L-serine dehydratase beta subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family.
  
 
 0.835
sdaA
L-serine dehydratase alpha subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family.
  
 
 0.835
metB1
Cystathionine gamma-synthase.
  
 
 0.832
metB2
Cystathionine beta-lyase.
  
 
 0.832
luxS
Autoinducer-2 production protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
  
  
  0.825
stu1972
Conserved hypothetical protein, truncated; Truncated.
   
 
 0.820
Your Current Organism:
Streptococcus thermophilus
NCBI taxonomy Id: 264199
Other names: S. thermophilus LMG 18311, Streptococcus thermophilus LMG 18311, Streptococcus thermophilus str. LMG 18311, Streptococcus thermophilus strain LMG 18311
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.